Evidence map›Paper›PMID 33211970›Full record

ArticleAmerican journal of respiratory and critical care medicine2021

From GOLD 0 to Pre-COPD.

MeiLan K Han, Alvar Agusti, Bartolome R Celli, Gerard J Criner, David M G Halpin, Nicolas Roche, Alberto Papi, Robert A Stockley, Jadwiga Wedzicha, Claus F Vogelmeier

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06571942 (Effect of the Inhaled Triple Therapies Over the Small Airway in Patients With Chronic Obstructive Pulmonary Disease or Chronic Bronchitis Without Obstruction Secondary to Biomass Exposure), which is not on this map. Cited by 168 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
168citing papers in PubMed, 4 pooled it
14.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06571942 phase4recruitingnot on this mapstarted 2023, after this paper: background citation

Effect of the Inhaled Triple Therapies Over the Small Airway in Patients With Chronic Obstructive Pulmonary Disease or Chronic Bronchitis Without Obstruction Secondary to Biomass Exposure: Randomized Controlled Clinical Trial Phase IV

TypeinterventionalSponsorNational Institute of Respiratory Diseases, MexicoRan2023 to 2025Enrolled128ConditionsCOPD Bronchitis, Pollution Related Respiratory DisorderArmsVilanterol / Umeclidinium (25/62.5 mcg), Fluthicasone / Vilanterol / Umeclidinium (100/25/62.5 mcg), Beclomethasone / Formoterol / Glycopyrronyum 100/6/12.5 mcg, Budesonide / Formoterol / Glycopyrronyum 160/4.8/7.2 mcg
3 · Its place in the literature

Who cites it

168 citing papers in PubMed, 4 syntheses or guidelines pooled it, 248 citations in OpenAlex.

  1. Pooled it
  2. Definitions of early COPD and predictors for disease progression: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. Pre-COPD, PRISm, and COPD in young adults born preterm.Annals of the American Thoracic Society · 2026
    Article
  10. Observational
  11. Observational
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Small airways dysfunction: associated factors, clinical aspects and new perspectives.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  18. Article
  19. Article
  20. Article

108 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 10 institutions in 6 countries.

MeiLan K HanDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0002-9095-4419
Alvar AgustiRespiratory Institute, Hospital Clinic, University of Barcelona, August Pi i Sunyer Biomedical Research Institute, Biomedical Research Networking Center on Respiratory Diseases, Madrid, Spain.
Bartolome R CelliDepartment of Medicine, Pulmonary, Brigham and Women's Hospital, Boston, Massachusetts.
Gerard J CrinerDepartment of Thoracic Medicine and Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania.
David M G HalpinCollege of Medicine and Health, University of Exeter Medical School, University of Exeter, Exeter, United Kingdom.
Nicolas RocheRespiratory Medicine, Cochin Hospital, APHP.Centre-University of Paris, Cochin Institute (UMR1016), Paris, France.
Alberto PapiRespiratory Division, Department of Translational Medicine, School of Medicine, University of Ferrara, Ferrera, Italy.
Robert A StockleyLung Investigation Unit, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham National Health Service Foundation Trust, Birmingham, United Kingdom.
Jadwiga WedzichaAirway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom; and.
Claus F VogelmeierDepartment of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, member of the German Center for Lung Research (DZL), Philipps-University, Marburg, Germany.
Brigham and Women's Hospital · USCentre for Biomedical Network Research on Rare Diseases · ESGerman Center for Lung Research · DEImperial College London · GBNational Health Service · GBTemple University · USUniversité Paris Cité · FRUniversity of Exeter · GBUniversity of Ferrara · ITUniversity of Michigan · US

Funding

Defining Pathways in COPD Patient Oriented ResearchK24HL138188 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MeiLan K Han · 2017 to 2026
$1.2M
NHLBI NIH HHS K24 HL138188
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAgedAged, 80 and overBiomarkersBronchodilator AgentsFemaleForced Expiratory VolumeHumansMaleMiddle AgedPulmonary Disease, Chronic ObstructiveSeverity of Illness IndexBiomarkersBronchodilator Agents

Identifiers

PMID33211970
PMCPMC7885837
OpenAlexW3102911407

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.