ArticleNeurospine2021
Hemodynamic Management of Acute Spinal Cord Injury: A Literature Review.
Article in Neurospine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of blood pressure threshold on adverse outcomes in patients with acute spinal cord injury: a systematic review and meta-analysis.Critical care (London, England) · 2025Pooled it
- Article
- Pharmacological and device-based interventions for paraplegia: A ClinicalTrials.gov-based analysis.Medicine · 2026Article
- Review
- Systemic Interleukin-4 Application Promotes Functional Recovery and Reprograms Neuroinflammatory and Molecular Responses after Spinal Cord Injury in Rats.Theranostics · 2026Article
- Article
- Surgical Timing After Spinal Cord Injury: A Narrative Review of Current Evidence and Perspectives.Korean journal of neurotrauma · 2025Review
- Potential Pharmacologic Treatments in Spinal Cord Injury: A Narrative Review.Korean journal of neurotrauma · 2025Review
- Timing of surgical intervention after firearm-related spinal cord injury.The journal of spinal cord medicine · 2025Article
- Perioperative management in acute and chronic spinal cord injury, narrative review.Journal of anesthesia, analgesia and critical care · 2025Review
- Management Protocols for Spinal Injuries in Adult Patients: A Clinical Guideline : Management Recommendations for Patients with Spinal Cord Injuries.Galen medical journal · 2025Article
- Autonomic dysfunction and hemodynamic management after acute spinal cord injury: blood pressure targets, perfusion strategies, and emerging therapies.Frontiers in neurology · 2025Review
- An Overview of Adult Acute Traumatic Neurologic Injury for the Anesthesiologist:Current anesthesiology reports · 2025Article
- Spinal Cord Infarction as an Atypical Thromboembolic Complication of First-Diagnosed Atrial Fibrillation.International medical case reports journal · 2025Article
- Surgical and Neurointensive Management for Acute Spinal Cord Injury: A Narrative Review.Korean journal of neurotrauma · 2024Review
- Critical Care of Spinal Cord Injury.Current neurology and neuroscience reports · 2024Review
- Advances and Challenges in Spinal Cord Injury Treatments.Journal of clinical medicine · 2024Review
- Evolving trends in the surgical, anaesthetic, and intensive care management of acute spinal cord injuries in the UK.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Article
- Spinal cord injury: Current trends in acute management.Brain & spine · 2024Review
- Co-Administration of Resolvin D1 and Peripheral Nerve-Derived Stem Cell Spheroids as a Therapeutic Strategy in a Rat Model of Spinal Cord Injury.International journal of molecular sciences · 2023Article
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Authors and funding
3 authors.
Funding
Abstract
The goal of acute spinal cord injury (SCI) management is to reduce secondary injuries and improve neurological recovery after its occurrence. This review aimed to explore the literature regarding hemodynamic management to reduce ischemic secondary injury and improve neurologic outcome following acute SCI. The PubMed database was searched for studies investigating blood flow, mean arterial pressure (MAP), and spinal cord perfusion pressure after SCI. The 2013 guidelines of the American Association of Neurological Surgeons/Congress of Neurological Surgeons recommended maintaining MAP at 85-90 mmHg for 7 days after SCI to potentially improve outcome. However, this recommendation was based on weak evidence for neurologic benefit. The maintenance of MAP will typically require vasopressors, which may have their own set of complications. More recently, studies have suggested the potential importance of considering spinal cord perfusion pressure in addition to the MAP. Further research on the hemodynamic management of acute SCI is required to determine how to optimize neurologic recovery. Evidence-based guidelines for hemodynamic management should acknowledge the gaps in knowledge and the limitations of the current literature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.