Evidence map›Paper›PMID 33211597›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2021

Renal medullary oxygenation decreases with lower body negative pressure in healthy young adults.

Danielle Jin-Kwang Kim, Rachel C Drew, Christopher T Sica, Qing X Yang, Amanda J Miller, Jian Cui, Michael D Herr, Lawrence I Sinoway

Open access · greenAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Danielle Jin-Kwang KimPenn State Heart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania.
Rachel C DrewPenn State Heart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania.ORCID 0000-0001-8001-1946
Christopher T SicaDepartment of Radiology, Penn State College of Medicine, Hershey, Pennsylvania.
Qing X YangDepartment of Radiology, Penn State College of Medicine, Hershey, Pennsylvania.
Amanda J MillerPenn State Heart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania.ORCID 0000-0002-6462-1039
Jian CuiPenn State Heart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania.
Michael D HerrPenn State Heart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania.
Lawrence I SinowayPenn State Heart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania.
Penn State Milton S. Hershey Medical Center · US

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
Project 3: Role Played by ASIC, P2X and EP4 Receptors in the Exercise Pressor Reflex in Health and Simulated PADP01HL134609 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2017 to 2021
$9.4M
NCATS NIH HHS UL1 TR002014NHLBI NIH HHS P01 HL134609
6 · The paper itself

Abstract

One in three Americans suffer from kidney diseases such as chronic kidney disease, and one of the etiologies is suggested to be long-term renal hypoxia. Interestingly, sympathetic nervous system activation evokes a renal vasoconstrictor effect that may limit oxygen delivery to the kidney. In this report, we sought to determine if sympathetic activation evoked by lower body negative pressure (LBNP) would decrease cortical and medullary oxygenation in humans. LBNP was activated in a graded fashion (LBNP; -10, -20, and -30 mmHg), as renal oxygenation was measured (T2*, blood oxygen level dependent, BOLD MRI;

Indexed as

Lower Body Negative PressureRenal CirculationHumansKidneySympathetic Nervous SystemVasoconstrictionYoung Adultrenal oxygenationrenal reflexessympathetic activation

Identifiers

PMID33211597
PMCPMC7944934
OpenAlexW3099931713

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.