Evidence map›Paper›PMID 33211332›Full record

ReviewHistopathology2021

Artificial intelligence and algorithmic computational pathology: an introduction with renal allograft examples.

Alton B Farris, Juan Vizcarra, Mohamed Amgad, Lee A D Cooper, David Gutman, Julien Hogan

Open access · greenAbstract readReview
In one paragraph

Review in Histopathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alton B FarrisDepartment of Pathology and Laboratory Medicine, Atlanta, GA, USA.ORCID https://orcid.org/0000-0001-5534-7763
Juan VizcarraDepartment of Bioinformatics, Emory University, Atlanta, GA, USA.
Mohamed AmgadDepartment of Pathology and Center for Computational Imaging and Signal Analytics, Northwestern University, Chicago, IL, USA.ORCID https://orcid.org/0000-0001-7599-6162
Lee A D CooperDepartment of Pathology and Center for Computational Imaging and Signal Analytics, Northwestern University, Chicago, IL, USA.ORCID https://orcid.org/0000-0002-3504-4965
David GutmanDepartment of Bioinformatics, Emory University, Atlanta, GA, USA.
Julien HoganDepartment of Surgery, Emory University, Atlanta, GA, USA.ORCID https://orcid.org/0000-0003-4838-9417
Emory University · USNorthwestern University · US

Funding

Advanced Development of an Open-source Platform for Web-based Integrative Digital Image Analysis in CancerU24CA194362 · NCI · EMORY UNIVERSITY · PI COOPER, LEE, GUTMAN, DAVID ANDREW · 2015 to 2019
$3.6M
Informatics Tools for Quantitative Digital Pathology Profiling and Integrated Prognostic ModelingU01CA220401 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI COOPER, LEE, FLOWERS, CHRISTOPHER R · 2018 to 2021
$1.3M
A new approach to predict graft outcome from histology in children undergoing kidney transplantation using machine learning methodsR21DK122229 · NIDDK · EMORY UNIVERSITY · PI HOGAN, JULIEN · 2019 to 2020
$461k
National Cancer Institute (NCI) U01CA220401National Cancer Institute (NCI) U24CA19436201National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 1R21DK122229-01NCI NIH HHS U01 CA220401NCI NIH HHS U24 CA194362NIDDK NIH HHS R21 DK122229
6 · The paper itself

Abstract

Whole slide imaging, which is an important technique in the field of digital pathology, has recently been the subject of increased interest and avenues for utilisation, and with more widespread whole slide image (WSI) utilisation, there will also be increased interest in and implementation of image analysis (IA) techniques. IA includes artificial intelligence (AI) and targeted or hypothesis-driven algorithms. In the overall pathology field, the number of citations related to these topics has increased in recent years. Renal pathology is one anatomical pathology subspecialty that has utilised WSIs and IA algorithms; it can be argued that renal transplant pathology could be particularly suited for whole slide imaging and IA, as renal transplant pathology is frequently classified by use of the semiquantitative Banff classification of renal allograft pathology. Hypothesis-driven/targeted algorithms have been used in the past for the assessment of a variety of features in the kidney (e.g. interstitial fibrosis, tubular atrophy, inflammation); in recent years, the amount of research has particularly increased in the area of AI/machine learning for the identification of glomeruli, for histological segmentation, and for other applications. Deep learning is the form of machine learning that is most often used for such AI approaches to the 'big data' of pathology WSIs, and deep learning methods such as artificial neural networks (ANNs)/convolutional neural networks (CNNs) are utilised. Unsupervised and supervised AI algorithms can be employed to accomplish image or semantic classification. In this review, AI and other IA algorithms applied to WSIs are discussed, and examples from renal pathology are covered, with an emphasis on renal transplant pathology.

Indexed as

Artificial IntelligenceKidney TransplantationAllograftsHumansImage Processing, Computer-AssistedKidneyKidney DiseasesMachine Learningartificial intelligencedigital pathologyimage analysismachine learningrenal transplant pathology

Identifiers

PMID33211332
PMCPMC8715391
OpenAlexW3106334361

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.