ArticleMovement disorders : official journal of the Movement Disorder Society2021
Resting-State Functional Connectivity Predicts STN DBS Clinical Response.
Article in Movement disorders : official journal of the Movement Disorder Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07024875 (Precision Neuroimaging of Parkinson's Disease), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Precision Neuroimaging of Parkinson's Disease
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Use of Functional MRI in Deep Brain Stimulation in Parkinson's Diseases: A Systematic Review.Frontiers in neurology · 2022Pooled it
- Lateralized Subthalamic Stimulation for Axial Dysfunction in Parkinson's Disease: Exploratory Outcomes and Open-Label Extension.Movement disorders clinical practice · 2024Trial
- White Matter Integrity Correlates with Strength of Response to Deep Brain Stimulation in Treatment-Resistant Obsessive-Compulsive Disorder.medRxiv : the preprint server for health sciences · 2026Article
- Preoperative Functional Connectivity Predicts Antiparkinson Drug Change after Deep Brain Stimulation.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Considerations for conducting developmental neuroimaging research on mental health topics.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Functional Connectivity and Volumetrics Improve Outcome Prediction for Deep Brain Stimulation in Parkinson's Disease.Movement disorders clinical practice · 2025Article
- Preoperative structural networks based on DTI predicts initial subthalamic nucleus stimulation outcome in parkinson's disease.Scientific reports · 2025Article
- Electrophysiological Alterations in the Progression of Parkinson's Disease and the Therapeutic Effect of Tetrabenazine on Rats With Levodopa-Induced Dyskinesia.CNS neuroscience & therapeutics · 2025Article
- Individualized cortico-basal ganglia network effective connectivity predicts outcomes of STN-DBS in patients with Parkinson's disease.Frontiers in neuroscience · 2025Article
- Revealing connectivity patterns of deep brain stimulation efficacy in Parkinson's disease.Scientific reports · 2024Article
- New Perspectives of Deep Brain Stimulation Indications for Parkinson's Disease: A Critical Review.Brain sciences · 2024Review
- The Role of Levodopa Challenge in Predicting the Outcome of Subthalamic Deep Brain Stimulation.Movement disorders clinical practice · 2023Article
- The effect of deep brain stimulation in Parkinson's disease reflected in EEG microstates.NPJ Parkinson's disease · 2023Article
- Altered Functional Connectivity of the Subthalamic Nucleus in Parkinson's Disease: Focus on Candidates for Deep Brain Stimulation.Journal of Parkinson's disease · 2023Article
- Profiles of resting state functional connectivity in temporal lobe epilepsy associated with post-laser interstitial thermal therapy seizure outcomes and semiologies.Frontiers in neuroimaging · 2023Article
- Motor learning is independent of effects of subthalamic deep brain stimulation on motor execution.Brain communications · 2023Article
- Risk Factors for Hiccups after Deep Brain Stimulation of Subthalamic Nucleus for Parkinson's Disease.Brain sciences · 2022Article
- Deep brain-machine interfaces: sensing and modulating the human deep brain.National science review · 2022Review
- Network structure mediates functional reorganization induced by optogenetic stimulation of non-human primate sensorimotor cortex.iScience · 2022Article
- Functional connectivity in Parkinson's disease candidates for deep brain stimulation.NPJ Parkinson's disease · 2022Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundDeep brain stimulation of the subthalamic nucleus is a widely used adjunctive therapy for motor symptoms of Parkinson's disease, but with variable motor response. Predicting motor response remains difficult, and novel approaches may improve surgical outcomes as well as the understanding of pathophysiological mechanisms. The objective of this study was to determine whether preoperative resting-state functional connectivity MRI predicts motor response from deep brain stimulation of the subthalamic nucleus.
methodsWe collected preoperative resting-state functional MRI from 70 participants undergoing subthalamic nucleus deep brain stimulation. For this cohort, we analyzed the strength of STN functional connectivity with seeds determined by stimulation-induced (ON/OFF)
resultsPreoperative functional connectivity between the left subthalamic nucleus and the ipsilateral internal globus pallidus correlated with postsurgical motor outcomes (r = -0.39, P = 0.0007), with stronger preoperative functional connectivity relating to greater improvement. Left pallidal-subthalamic nucleus connectivity also predicted motor response to DBS after controlling for covariates. DISCUSSION: Preoperative pallidal-subthalamic nucleus resting-state functional connectivity predicts motor benefit from deep brain stimulation, although this should be validated prospectively before clinical application. These observations suggest that integrity of pallidal-subthalamic nucleus circuits may be critical to motor benefits from deep brain stimulation. © 2020 International Parkinson and Movement Disorder Society.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.