ReviewReproductive sciences (Thousand Oaks, Calif.)2021
Fetal Growth Restriction: Does an Integrated Maternal Hemodynamic-Placental Model Fit Better?
Review in Reproductive sciences (Thousand Oaks, Calif.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 74 citations in OpenAlex.
- Effect of nitric oxide donor and plasma volume expansion on pregnancies with early onset fetal growth restriction: a randomized controlled trial.Archives of gynecology and obstetrics · 2025Trial
- Maternal Cardiovascular Phenotype in Fetal Growth Restriction with or Without Pre-Eclampsia: Insights from Echocardiography and Clinical Implications.Diagnostics (Basel, Switzerland) · 2026Review
- Diagnostic value of the myocardial performance index and doppler parameters in detecting fetal growth restriction in pregnancies complicated by hypertensive disorders.Quantitative imaging in medicine and surgery · 2026Article
- The KISS1/KISS1R Axis in Human Placentation: Molecular Mechanisms and Implications for Foetal Growth Restriction and Pre-Eclampsia.International journal of molecular sciences · 2026Review
- Placental iron utilisation in fetal growth restriction: alterations in mitochondrial haem synthesis and iron-sulphur cluster assembly pathways.The Journal of physiology · 2026Article
- The Impact of Fetal Growth Restriction on Myocardial Development from Fetal Life to Early Childhood: A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Low PAPP-A levels and their association with adverse perinatal outcomes in twin pregnancies.Archives of gynecology and obstetrics · 2026Article
- The correlation of umbilical cord blood quality and placental function with neonatal outcomes in fetal growth restriction.Frontiers in medicine · 2026Article
- Obstetric outcome in women with congenital heart disease: A nationwide cohort in Sweden.Acta obstetricia et gynecologica Scandinavica · 2026Article
- ISUOG Consensus Statement on maternal hemodynamic assessment in hypertensive disorders of pregnancy and fetal growth restriction.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025Article
- Immunoregulatory Imbalance in Preeclampsia: A Cross-Sectional Study of B7-H3 and Decidual NK Cell Interactions.Medical sciences (Basel, Switzerland) · 2025Article
- Non-invasive prediction of fetal growth restriction in pre-eclampsia: integrating peripheral blood endothelial progenitor cell count with uterine artery Doppler velocimetry.Archives of gynecology and obstetrics · 2025Article
- The role of 1-Deoxysphingolipids and Polyamines in the pathogenesis of placental syndrome.BMC pregnancy and childbirth · 2025Article
- Exploring the Potential of Peptides Derived from the Coelomic Fluid ofF1000Research · 2025Article
- Impaired maternal central hemodynamics precede the onset of vascular disorders of pregnancy at high altitude.American journal of physiology. Heart and circulatory physiology · 2025Article
- The central role of creatine and polyamines in fetal growth restriction.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Fetal Splenic Artery Pulsatility Index May Predict the Need for Neonatal Intensive Care in Gestational Diabetes Class A1 Cases.Journal of personalized medicine · 2024Article
- Early Fetal Growth Restriction with or Without Hypertensive Disorders: a Clinical Overview.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- Observational
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Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, a growing interest has arisen regarding the possible relationship between adverse pregnancy outcomes (APOs) and inadequate maternal hemodynamic adaptations to the pregnancy. A possible association between "placental syndromes," such as preeclampsia (PE) and fetal growth restriction (FGR), and subsequent maternal cardiovascular diseases (CVD) later in life has been reported. The two subtypes of FGR show different pathogenetic and clinical features. Defective placentation, due to a poor trophoblastic invasion of the maternal spiral arteries, is believed to play a central role in the pathogenesis of early-onset PE and FGR. Since placental functioning is dependent on the maternal cardiovascular system, a pre-existent or subsequent cardiovascular impairment may play a key role in the pathogenesis of early-onset FGR. Late FGR does not seem to be determined by a primary abnormal placentation in the first trimester. The pathological pathway of late-onset FGR may be due to a primary maternal cardiovascular maladaptation: CV system shows a flat profile and remains similar to those of non-pregnant women. Since the second trimester, when the placenta is already developed and increases its functional request, a hypovolemic state could lead to placental hypoperfusion and to an altered maturation of the placental villous tree and therefore to an altered fetal growth. Thus, this review focalizes on the possible relationship between maternal cardiac function and placentation in the development of both early and late-onset FGR. A better understanding of maternal hemodynamics in pregnancies complicated by FGR could bring various benefits in clinical practice, improving screening and therapeutic tools.
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