ArticleBulletin of mathematical biology2020
Electro-physiology Models of Cells with Spherical Geometry with Non-conducting Center.
Article in Bulletin of mathematical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Electrowriting patterns and electric field harness directional cell migration for skin wound healing.Materials today. Bio · 2024Article
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3 authors.
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Abstract
We study the flow of electrical currents in spherical cells with a non-conducting core, so that current flow is restricted to a thin shell below the cell's membrane. Examples of such cells are fat storing cells (adipocytes). We derive the relation between current and voltage in the passive regime and examine the conditions under which the cell is electro-tonically compact. We compare our results to the well-studied case of electrical current flow in cylinder structures, such as neurons, described by the cable equation. In contrast to the cable, we find that for the sphere geometry (1) the voltage profile across the cell depends critically on the electrode geometry, and (2) the charging and discharging can be much faster than the membrane time constant; however, (3) voltage clamp experiments will incur similar distortion as in the cable case. We discuss the relevance for adipocyte function and experimental electro-physiology.
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