ArticleJournal of neurology2021
Cognitive impairments are independently associated with shorter survival in diffuse glioma patients.
Article in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Factors affecting cognitive functions of patients with high-grade gliomas: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Pooled it
- A systematic review of cognitive interventions for adult patients with brain tumours.Cancer medicine · 2023Pooled it
- Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.The Cochrane database of systematic reviews · 2022Pooled it
- Clinical Predictors of Survival After Palliative Radiotherapy for Glioblastoma in a Real-World Cohort Study.Current oncology (Toronto, Ont.) · 2026Article
- Impact of Subventricular Zone Invasion on Preoperative Cognitive Decline in Patients with Diffuse Glioma.Neurosurgery · 2026Article
- A Language Performance Model for Predicting Glioma Recurrence and Molecular Biomarkers: A Retrospective Cohort Study.Brain and behavior · 2026Article
- Review of glioblastoma and systemic comorbidities.Frontiers in oncology · 2026Review
- Factors associated with cognitive impairment in long-term IDH-mutant glioma survivors.Journal of neuro-oncology · 2025Article
- Tumor resting-state fMRI connectivity to extralesional brain is associated with cognitive performance in glioma patients.Brain & spine · 2025Article
- Cognitive Rehabilitation of Brain Tumor Survivors: A Systematic Review.Brain tumor research and treatment · 2025Review
- Do presenting symptoms predict treatment decisions and survival in glioblastoma? Real-world data from 1458 patients in the Swedish brain tumor registry.Neuro-oncology practice · 2024Article
- Age-independent benefits of postoperative rehabilitation during chemoradiotherapy on functional outcomes and survival in patients with glioblastoma.Journal of neuro-oncology · 2024Article
- Perioperative Neurocognitive Function in Glioma Surgery.Current oncology reports · 2024Review
- Cognition and health-related quality of life in long-term survivors of high-grade glioma: an interactive perspective from patient and caregiver.Acta neurochirurgica · 2024Article
- Association of body mass index with clinical outcome of primary WHO grade 4 glioma.Frontiers in oncology · 2024Article
- Should simple bedside neurocognitive data now be routinely gathered prior to brain tumor surgery?Neuro-oncology practice · 2023Article
- Preoperative neurocognitive function as an independent survival prognostic marker in primary glioblastoma.Neuro-oncology practice · 2023Article
- Real-Time Neuropsychological Testing (RTNT) and Music Listening during Glioblastoma Excision in Awake Surgery: A Case Report.Journal of clinical medicine · 2023Article
- The dynamic functional connectivity fingerprint of high-grade gliomas.Scientific reports · 2023Article
- Incidence of clinically relevant psychiatric symptoms during glioblastoma treatment: an exploratory study.Journal of neuro-oncology · 2023Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiffuse gliomas (WHO grade II-IV) are progressive primary brain tumors with great variability in prognosis. Cognitive deficits are of important prognostic value for survival in diffuse gliomas. Until now, few studies focused on domain-specific neuropsychological assessment and rather used MMSE as a measure for cognitive functioning. Additionally, these studies did not take WHO 2016 diagnosis into account. We performed a retrospective cohort study with the aim to investigate the independent relationship between cognitive functioning and survival in treatment-naive patients undergoing awake surgery for a diffuse glioma.
methodsIn patients undergoing awake craniotomy between 2010 and 2017, we performed pre-operative neuropsychological assessments in five cognitive domains, with special attention for the domains executive functioning and memory. We evaluated the independent relation between these domains and survival, in a Cox proportional hazards model that included state-of-the-art integrated histomolecular ('layered' or WHO-2016) classification of the gliomas and other known prognostic factors.
resultsWe included 197 patients. Cognitive impairments (Z-values ≦ - 2.0) were most frequent in the domains memory (18.3%) and executive functioning (25.9%). Impairments in executive functioning and memory were significantly correlated with survival, even after correcting for the possible confounders. Analyses with the domains language, psychomotor speed, and visuospatial functioning yielded no significant results. Extensive domain-specific neuropsychological assessment was more strongly correlated to survival than MMSE.
conclusionCognitive functioning is independently related to survival in diffuse glioma patients. Possible mechanisms underlying this relationship include the notion of cognitive functioning as a marker for diffuse infiltration of the tumor and the option that cognitive functioning and survival are determined by overlapping genetic pathways and biomarkers.
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