Evidence map›Paper›PMID 33211150›Full record

ArticleAbdominal radiology (New York)2021

Non-invasive assessment of cirrhosis using multiphasic dual-energy CT iodine maps: correlation with model for end-stage liver disease score.

Domenico Mastrodicasa, Martin J Willemink, Celina Duran, Andrea Delli Pizzi, Virginia Hinostroza, Lior Molvin, Mohamed Khalaf, R Brooke Jeffrey, Bhavik N Patel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Abdominal radiology (New York), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Spectral CT: Current Liver Applications.Diagnostics (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Domenico MastrodicasaDepartment of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, Rm H1307, MC 5105, Stanford, CA, 94305, USA.ORCID 0000-0001-8227-0757
Martin J WilleminkDepartment of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, Rm H1307, MC 5105, Stanford, CA, 94305, USA.ORCID 0000-0002-6991-6557
Celina DuranBoston University School of Medicine, Boston, MA, USA.
Andrea Delli PizziDepartment of Neuroscience, Imaging and Clinical Sciences, ITAB Institute for Advanced Biomedical Technologies, "G. D'Annunzio" University, Chieti, Italy.ORCID 0000-0002-2011-3753
Virginia HinostrozaDepartment of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, Rm H1307, MC 5105, Stanford, CA, 94305, USA.ORCID 0000-0001-5761-6146
Lior MolvinDepartment of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, Rm H1307, MC 5105, Stanford, CA, 94305, USA.
Mohamed KhalafDepartment of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, Rm H1307, MC 5105, Stanford, CA, 94305, USA.
R Brooke JeffreyDepartment of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, Rm H1307, MC 5105, Stanford, CA, 94305, USA.
Bhavik N PatelDepartment of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, Rm H1307, MC 5105, Stanford, CA, 94305, USA. bhavikp@stanford.edu.ORCID 0000-0001-5157-9903
Stanford University · USUniversity of Chieti-Pescara · IT

Funding

Multi-Disciplinary Training Program in Cardiovascular Imaging at StanfordT32EB009035 · NIBIB · STANFORD UNIVERSITY · PI Koen Nieman, John M. Pauly · 2008 to 2026
$4.3M
National Institute of Biomedical Imaging and Bioengineering (US) 5T32EB009035NIBIB NIH HHS T32 EB009035
6 · The paper itself

Abstract

purposeTo determine whether multiphasic dual-energy (DE) CT iodine quantitation correlates with the severity of chronic liver disease.

methodsWe retrospectively included 40 cirrhotic and 28 non-cirrhotic patients who underwent a multiphasic liver protocol DECT. All three phases (arterial, portal venous (PVP), and equilibrium) were performed in DE mode. Iodine (I) values (mg I/ml) were obtained by placing regions of interest in the liver, aorta, common hepatic artery, and portal vein (PV). Iodine slopes (λ) were calculated as follows: (I

resultsCirrhotic and non-cirrhotic patients had significantly different λ

conclusionMultiphasic DECT iodine quantitation over time is significantly different between cirrhotic and non-cirrhotic patients, correlates with the MELD score, and it could potentially serve as a non-invasive measure of cirrhosis and disease severity with acceptable diagnostic accuracy.

Indexed as

End Stage Liver DiseaseIodineContrast MediaHumansLiverLiver CirrhosisRetrospective StudiesSeverity of Illness IndexTomography, X-Ray ComputedContrast MediaIodineChronic liver diseaseDual-energy CTIodine concentrationLiver cirrhosisMaterial decomposition

Identifiers

PMID33211150
PMCPMC9282666
OpenAlexW3103140622

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.