Evidence map›Paper›PMID 33211131›Full record

ArticleBulletin of environmental contamination and toxicology2020

N-phenyl-1-naphthylamine (PNA) Accumulates in Snapping Turtle (Chelydra serpentina) Liver Activating the Detoxification Pathway.

Tash-Lynn L Colson, Shane R de Solla, Vimal K Balakrishnan, John Toito, Valerie S Langlois

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bulletin of environmental contamination and toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Tash-Lynn L ColsonSchool of Environmental Studies, Queen's University, Kingston, ON, Canada.
Shane R de SollaEcotoxicology and Wildlife Health Division, Environment and Climate Change Canada, Burlington, ON, Canada.
Vimal K BalakrishnanAquatic Contaminants and Research Division, Environment and Climate Change Canada, Burlington, ON, Canada.
John ToitoAquatic Contaminants and Research Division, Environment and Climate Change Canada, Burlington, ON, Canada.
Valerie S LangloisSchool of Environmental Studies, Queen's University, Kingston, ON, Canada. Valerie.Langlois@inrs.ca.ORCID http://orcid.org/0000-0001-6281-5801
Environment and Climate Change Canada · CAQueen's University · CA

Funding

Canada Research Chairs 950-230492
6 · The paper itself

Abstract

Substituted phenylamine antioxidants (SPAs) are used in Canadian industrial processes. SPAs, specifically N-phenyl-1-naphthylamine (PNA), have received very little attention despite their current use in Canada and their expected aquatic and environmental releases. There is a research gap regarding the effects of PNA in wildlife; therefore, Chelydra serpentina (common snapping turtle) was studied due to its importance as an environmental indicator species. A chronic experiment was performed using PNA spiked food (0 to 3446 ng/g) to determine its toxicity to juvenile C. serpentina. A significant increase in cyp1a mRNA level was observed in the liver of turtles exposed to 3446 ng/g PNA, suggesting that phase I detoxification is activated in the exposed animals. Additionally, a significant decrease in cyp2b transcript level was observed at the two lowest PNA doses, likely indicating another metabolic alteration for PNA. This study helped determine the molecular effects associated with a PNA exposure in reptiles.

Indexed as

1-NaphthylamineAnimalsAnimals, WildCanadaLiverReptilesTurtles1-NaphthylamineN-phenyl-1-naphthylamineCytochrome P450MetabolismN-phenyl-1-naphthylamineToxicityTurtle

Identifiers

PMID33211131
PMCPMC7716939
OpenAlexW3099306178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.