ArticleMolecular biology and evolution2021
Genomic Analysis Enlightens Agaricales Lifestyle Evolution and Increasing Peroxidase Diversity.
Article in Molecular biology and evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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62 citing papers in PubMed, 136 citations in OpenAlex.
- Molecular biology of Pleurotus mushrooms: genomic resources, genetic manipulation, and regulation mechanisms.Antonie van Leeuwenhoek · 2026Review
- Hybrid Genome Assembly and Annotation of the Basidiomycete FungusInternational journal of molecular sciences · 2026Article
- Systematic study ofIMA fungus · 2026Article
- Genomic and Transcriptomic Insights into Carbon-Source and Temporal Induction of a Diverse Set of Lignocellulolytic Enzymes inJournal of fungi (Basel, Switzerland) · 2025Article
- Cross-kingdom comparative genomics reveal the metabolic potential of fungi for lignin turnover in deadwood.Nature ecology & evolution · 2025Article
- Chromosome-Level Genome Announcement of the MonokaryoticJournal of fungi (Basel, Switzerland) · 2025Article
- Aryl-alcohol oxidases: catalysis, diversity, structure-function and emerging biotechnological applications.Applied microbiology and biotechnology · 2025Review
- Fungal Coculture: Unlocking the Potential for Efficient Bioconversion of Lignocellulosic Biomass.Journal of fungi (Basel, Switzerland) · 2025Review
- Morphogenesis, starvation, and light responses in a mushroom-forming fungus revealed by long-read sequencing and extensive expression profiling.Cell genomics · 2025Article
- Linking the Metabolic Activity of Plastic-Degrading Fungi to Their Taxonomy and Evolution.Journal of fungi (Basel, Switzerland) · 2025Review
- Illuminating ecology and distribution of the rare fungus Phellinidium pouzarii in the Bavarian Forest National Park.Scientific reports · 2025Article
- Haplotype-resolved genomes ofIMA fungus · 2025Article
- Six Unrecorded Species of Agaricales (Agaricomycetes, Basidiomycota) from Mudeungsan National Park in Korea.Mycobiology · 2025Article
- Saprotrophic Wood Decay Ability and Plant Cell Wall Degrading Enzyme System of the White Rot FungusJournal of fungi (Basel, Switzerland) · 2024Article
- Comparative genomics reveals carbohydrate enzymatic fluctuations and herbivorous adaptations in arthropods.Computational and structural biotechnology journal · 2024Article
- Comparative analyses ofComputational and structural biotechnology journal · 2024Article
- Impact of Agroforestry Practices on Soil Microbial Diversity and Nutrient Cycling in Atlantic Rainforest Cocoa Systems.International journal of molecular sciences · 2024Article
- Extreme overall mushroom genome expansion in Mycena s.s. irrespective of plant hosts or substrate specializations.Cell genomics · 2024Article
- Structure-function characterization of two enzymes from novel subfamilies of manganese peroxidases secreted by the lignocellulose-degrading Agaricales fungi Agrocybe pediades and Cyathus striatus.Biotechnology for biofuels and bioproducts · 2024Article
- Quorum sensing in bacteria: in silico protein analysis, ecophysiology, and reconstruction of their evolutionary history.BMC genomics · 2024Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
36 authors at 12 institutions in 5 countries.
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No grant is acknowledged in the PubMed record.
Abstract
As actors of global carbon cycle, Agaricomycetes (Basidiomycota) have developed complex enzymatic machineries that allow them to decompose all plant polymers, including lignin. Among them, saprotrophic Agaricales are characterized by an unparalleled diversity of habitats and lifestyles. Comparative analysis of 52 Agaricomycetes genomes (14 of them sequenced de novo) reveals that Agaricales possess a large diversity of hydrolytic and oxidative enzymes for lignocellulose decay. Based on the gene families with the predicted highest evolutionary rates-namely cellulose-binding CBM1, glycoside hydrolase GH43, lytic polysaccharide monooxygenase AA9, class-II peroxidases, glucose-methanol-choline oxidase/dehydrogenases, laccases, and unspecific peroxygenases-we reconstructed the lifestyles of the ancestors that led to the extant lignocellulose-decomposing Agaricomycetes. The changes in the enzymatic toolkit of ancestral Agaricales are correlated with the evolution of their ability to grow not only on wood but also on leaf litter and decayed wood, with grass-litter decomposers as the most recent eco-physiological group. In this context, the above families were analyzed in detail in connection with lifestyle diversity. Peroxidases appear as a central component of the enzymatic toolkit of saprotrophic Agaricomycetes, consistent with their essential role in lignin degradation and high evolutionary rates. This includes not only expansions/losses in peroxidase genes common to other basidiomycetes but also the widespread presence in Agaricales (and Russulales) of new peroxidases types not found in wood-rotting Polyporales, and other Agaricomycetes orders. Therefore, we analyzed the peroxidase evolution in Agaricomycetes by ancestral-sequence reconstruction revealing several major evolutionary pathways and mapped the appearance of the different enzyme types in a time-calibrated species tree.
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