Evidence map›Paper›PMID 33211005›Full record

ArticleeLife2020

Robo functions as an attractive cue for glial migration through SYG-1/Neph.

Zhongwei Qu, Albert Zhang, Dong Yan

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. A gene expression atlas of a juvenile nervous system.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Glia Development and Function in the NematodeCold Spring Harbor perspectives in biology · 2024
    Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Zhongwei QuDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, United States.ORCID 0000-0002-6994-0530
Albert ZhangDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, United States.ORCID 0000-0003-1310-5680
Dong YanDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, United States.ORCID 0000-0002-7542-1251
Duke University · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Genetic study of gap junction formation and regulation in C. elegans neuronsR01NS105638 · NINDS · DUKE UNIVERSITY · PI YAN, DONG · 2018 to 2022
$1.8M
Mechanisms of neural circuit formation in C. elegansR01NS094171 · NINDS · DUKE UNIVERSITY · PI YAN, DONG · 2015 to 2019
$1.5M
NIH HHS P40 OD010440NINDS NIH HHS R01 NS094171NINDS NIH HHS R01 NS105638
6 · The paper itself

Abstract

As one of the most-studied receptors, Robo plays functions in many biological processes, and its functions highly depend on Slit, the ligand of Robo. Here we uncover a Slit-independent role of Robo in glial migration and show that neurons can release an extracellular fragment of Robo upon cleavage to attract glia during migration in

Indexed as

Cell MovementAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsImmunoglobulinsNerve Tissue ProteinsNeurogliaReceptors, ImmunologicRoundabout ProteinsCaenorhabditis elegans ProteinsImmunoglobulinsNerve Tissue ProteinsReceptors, ImmunologicRoundabout ProteinsSYG-1 protein, C elegansC. eleganscleavageglial migrationneuroscienceRoboSYG-1

Identifiers

PMID33211005
PMCPMC7676865
OpenAlexW3100615658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.