Evidence map›Paper›PMID 33210729›Full record

ArticleAllergy2021

Distinct expression of SARS-CoV-2 receptor ACE2 correlates with endotypes of chronic rhinosinusitis with nasal polyps.

Ming Wang, Xiangting Bu, Gaoli Fang, Ge Luan, Yanran Huang, Cezmi A Akdis, Chengshuo Wang, Luo Zhang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Allergy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Evaluation of Angiotensin-Converting Enzyme 2 ExpressionACS pharmacology & translational science · 2024
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Viral infections and chronic rhinosinusitis.The Journal of allergy and clinical immunology · 2023
    Review
  12. Article
  13. Chronic Rhinosinusitis and COVID-19.The journal of allergy and clinical immunology. In practice · 2022
    Review
  14. Article
  15. Article
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  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Ming WangDepartment of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-8560-3964
Xiangting BuDepartment of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
Gaoli FangDepartment of Otolaryngology, Head and Neck Surgery, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Ge LuanDepartment of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
Yanran HuangDepartment of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.ORCID 0000-0001-5755-7684
Cezmi A AkdisSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.ORCID 0000-0001-8020-019X
Chengshuo WangDepartment of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.ORCID 0000-0003-0646-5135
Luo ZhangDepartment of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-0910-9884
Beijing Tongren Hospital · CNCapital Medical University · CNUniversity of Zurich · CH

Funding

Beijing municipal administration of hospitals clinical medicine development of special funding support XMLX201816Beijing municipal administration of hospitals' Dengfeng plan DFL20190202Beijing municipal administration of hospitals' mission plan SML20150203national key R&D program of China 2016YFC0905200national key R&D program of China 2018YFC0116800National Natural Science Foundation of China 81630023National Natural Science Foundation of China 81800882National Natural Science Foundation of China 81870698program for the Changjiang scholars and innovative research team IRT13082
6 · The paper itself

Abstract

backgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry factors, ACE2 and TMPRSS2, are highly expressed in nasal epithelial cells. However, the association between SARS-CoV-2 and nasal inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP) has not been investigated. We thus investigated the expression of SARS-CoV-2 entry factors in nasal tissues of CRSwNP patients, and their associations with inflammatory endotypes of CRSwNP.

methodsThe expression of ACE2 and TMPRSS2 was assessed in nasal tissues of control subjects and eosinophilic CRSwNP (ECRSwNP) and nonECRSwNP patients. The correlations between ACE2/TMPRSS2 expression and inflammatory indices of CRSwNP endotypes were evaluated. Regulation of ACE2/TMPRSS2 expression by inflammatory cytokines and glucocorticoids was investigated.

resultsACE2 expression was significantly increased in nasal tissues of nonECRSwNP patients compared to ECRSwNP patients and control subjects, and positively correlated with the expression of IFN-γ, but negatively correlated with tissue infiltrated eosinophils, and expression of IL5 and IL13. IFN-γ up-regulated ACE2 expression while glucocorticoid attenuated this increase in cultured nasal epithelial cells. Genes co-expressed with ACE2 were enriched in pathways relating to defence response to virus in nasal tissue. TMPRSS2 expression was decreased in nasal tissues of CRSwNP patients compared to control subjects and not correlated with the inflammatory endotypes of CRSwNP. Glucocorticoid treatment decreased ACE2 expression in nasal tissues of nonECRSwNP patients, but not in ECRSwNP patients, whereas TMPRSS2 expression was not affected.

conclusionThese findings indicate that ACE2 expression, regulated by IFN-γ, is increased in nasal tissues of nonECRSwNP patients and positively correlates with type 1 inflammation.

Indexed as

AdultAngiotensin-Converting Enzyme 2Cells, CulturedChronic DiseaseCOVID-19FemaleGene Expression Regulation, EnzymologicGlucocorticoidsHumansMaleMiddle AgedNasal PolypsReceptors, CoronavirusRhinitisSerine EndopeptidasesSinusitisACE2 protein, humanAngiotensin-Converting Enzyme 2GlucocorticoidsHPN protein, humanReceptors, CoronavirusSerine EndopeptidasesACE2chronic rhinosinusitis with nasal polypsinflammatory endotypeSARS-CoV-2TMPRSS2

Identifiers

PMID33210729
PMCPMC7753806
OpenAlexW3106074963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.