ArticleProceedings of the National Academy of Sciences of the United States of America1987
Genetic analysis of tumorigenesis: a conserved region in the human and Chinese hamster genomes contains genetically identified tumor-suppressor genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 27 citations in OpenAlex.
- A specific chromosome change and distinctive transforming genes are necessary for malignant progression of spontaneous transformation in cultured Chinese hamster embryo cells.Japanese journal of cancer research : Gann · 1995Article
- Immunohistochemical and molecular analysis of p53, MDM2, proliferating cell nuclear antigen and Ki67 in benign and malignant peripheral nerve sheath tumours.Virchows Archiv : an international journal of pathology · 1995Article
- Menadione-resistant Chinese hamster cell variants are cross-resistant to hydrogen peroxide and exhibit stable chromosomal and biochemical alterations.Molecular and cellular biochemistry · 1992Article
- Overlapping loss of heterozygosity by mitotic recombination on mouse chromosome 7F1-ter in skin carcinogenesis.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Genetic and synteny mapping of parathyroid hormone and beta hemoglobin in cattle.Biochemical genetics · 1989Article
- Functional diversity of gro gene expression in human fibroblasts and mammary epithelial cells.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
- The short arm of chromosome 11 is a "hot spot" for hypermethylation in human neoplasia.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
Regional chromosome homologies were found in a comparison of human 11p with Chinese hamster 3p. By use of probes that recognize six genes of human 11p (INS, CAT, HBBC, CALC, PTH, and HRAS), the corresponding genes were localized by in situ hybridization on Chinese hamster chromosome 3. INS and CAT were located close to the centromere on 3p, whereas HBBC, CALC, and PTH were at 3q3-4 and HRAS at 3q4. Extensive prior data from chromosome studies of tumorigenic and tumor-derived Chinese hamster cells have suggested the presence of a tumor-suppressor gene on 3p. Two tumor-suppressor genes have been described on human 11p, one linked to CAT and one to INS. The present study raises the possibility that the Chinese hamster suppressor may be closely linked to INS or CAT.
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