ArticleeLife2020
Plasma proteomic biomarker signature of age predicts health and life span.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06975111 (Focusing on the Menopausal Transition to Improve Mid-Life Women's Health), which is not on this map. Cited by 148 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Focusing on the Menopausal Transition to Improve Mid-Life Women's Health
Who cites it
148 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Proteomic Markers of Aging and Longevity: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Proteomic Analysis of the Senescence-Associated Secretory Phenotype: GDF-15, IGFBP-2, and Cystatin-C Are Associated With Multiple Aging Traits.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Pooled it
- Biomarkers of Cellular Senescence Predict the Onset of Mobility Disability and Are Reduced by Physical Activity in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Trial
- Trial
- A compendium of circulating biomarkers of senescence in humans: Insights on mechanistic impact across health domains and modulation by therapeutic interventions.Ageing research reviews · 2026Review
- Combating ageing beyond the cell: Emerging roles of extracellular proteostasis.The FEBS journal · 2026Review
- Structural decomposition enables multi-omics dissection of common and organ-specific aging.Science China. Life sciences · 2026Article
- Aptamer-Based Platforms for Human Aging Biomarkers: Multiplexed Proteomics, Biosensors and Translational Perspectives.International journal of molecular sciences · 2026Review
- Identification of Age-Associated Circulating Proteins and Lipids in 3800 Comorbidity-Enriched Older Adults from Japan-Based Cohorts Using Olink Assays and MRM Mass Spectrometry.Journal of proteome research · 2026Article
- Urinary metabolic age from high-resolution nuclear magnetic resonance spectroscopy reveals longitudinal aging patterns.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Deep Learning-Derived Retinal Age Detects Cognitive Impairment.Ophthalmology science · 2026Article
- Peripheral transcriptomic aging acceleration in major depressive disorder: the mediating role of insular cortex alterations.Psychological medicine · 2026Article
- Associations of proteomic age clocks with lifestyle risk factors, incident chronic diseases and mortality in two European cohorts.Nature aging · 2026Article
- Thermophysiological BioEnergy Index as a Biomarker of Biological Ageing: A Large-Scale Microwave Radiometry Study.Diagnostics (Basel, Switzerland) · 2026Article
- Circulating cell type senescence signatures track distinct dimensions of health status and trajectories in human longitudinal cohorts.Cell reports · 2026Article
- ProtFI, an efficient frailty-trained proteomics-based biomarker of aging, robustly predicts age-related decline.Cell reports methods · 2026Article
- StackAge: an ensemble-based clock for precise quantification of biological age using multi-omics data.Briefings in bioinformatics · 2026Article
- Multi-Omics Signatures of Organ Clocks in Biological Aging and Disease: A Conceptual Framework for Organ-Specific Aging Clocks.Aging cell · 2026Review
- Longitudinal protein profiling of blood during childhood into early adulthood.Nature communications · 2026Article
- Plasma Proteomic Profiling of Young and Older Adults Identifies Candidate Biomarkers of Biological Aging at the Intersection of Age and Disease.Aging cell · 2026Article
88 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Older age is a strong shared risk factor for many chronic diseases, and there is increasing interest in identifying aging biomarkers. Here, a proteomic analysis of 1301 plasma proteins was conducted in 997 individuals between 21 and 102 years of age. We identified 651 proteins associated with age (506 over-represented, 145 underrepresented with age). Mediation analysis suggested a role for partial
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.