Evidence map›Paper›PMID 33210566›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2021

Cell-specific activation of RIPK1 and MLKL after intracerebral hemorrhage in mice.

Sevda Lule, Limin Wu, Aliyah Sarro-Schwartz, William J Edmiston, Saef Izzy, Tanya Songtachalert, So Hee Ahn, Neil D Fernandes, Gina Jin, Joon Yong Chung and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 31 citations in OpenAlex.

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  20. Modes of Brain Cell Death Following Intracerebral Hemorrhage.Frontiers in cellular neuroscience · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Sevda LuleDepartment of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Limin WuDepartment of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Aliyah Sarro-SchwartzDepartment of Neurology, Brigham and Woman's Hospital, Harvard Medical School, Boston, MA, USA.
William J EdmistonDepartment of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Saef IzzyDepartment of Neurology, Brigham and Woman's Hospital, Harvard Medical School, Boston, MA, USA.
Tanya SongtachalertDepartment of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
So Hee AhnDepartment of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Neil D FernandesDepartment of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.ORCID 0000-0002-3024-1994
Gina JinDepartment of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Joon Yong ChungDepartment of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Siddharth BalachandranBlood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
Eng H LoDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
David KaplanDepartment of Biomedical Engineering, Tufts University, Medford, MA, USA.
Alexei DegterevDepartment of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA.
Michael J WhalenDepartment of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Harvard University · USTufts University · USFox Chase Cancer Center · US

Funding

RIP1/3 Kinases as New Targets in Malignant MesotheliomaR01CA190542 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI BALACHANDRAN, SIDDHARTH, TESTA, JOSEPH R. · 2015 to 2019
$2.1M
Plasmalemma permeability and necroptosis: New targets for intracerebral hemoR01NS071072 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI WHALEN, MICHAEL J · 2012 to 2016
$1.8M
Functional three dimensional brain-like tissues to study mechanisms of traumatic brain injuryR01NS092847 · NINDS · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2015 to 2019
$1.8M
Dissection of the new pro-inflammatory components of the necrosome complexR21AI124049 · NIAID · TUFTS UNIVERSITY BOSTON · PI DEGTEREV, ALEXEI, GERBER, SCOTT A. · 2017 to 2018
$466k
Targeting RIPK1 and RIPK2 kinases in mouse Experimental Autoimmune EncephalomyelitisR21NS111395 · NINDS · TUFTS UNIVERSITY BOSTON · PI CUNY, GREGORY D, DEGTEREV, ALEXEI · 2019 to 2019
$458k
NCI NIH HHS R01 CA190542NIAID NIH HHS R21 AI124049NINDS NIH HHS R01 NS071072NINDS NIH HHS R01 NS092847NINDS NIH HHS R21 NS111395
6 · The paper itself

Abstract

Receptor-interacting protein kinase-1 (RIPK1) is a master regulator of cell death and inflammation, and mediates programmed necrosis (necroptosis) via mixed-lineage kinase like (MLKL) protein. Prior studies in experimental intracerebral hemorrhage (ICH) implicated RIPK1 in the pathogenesis of neuronal death and cognitive outcome, but the relevant cell types involved and potential role of necroptosis remain unexplored. In mice subjected to autologous blood ICH, early RIPK1 activation was observed in neurons, endothelium and pericytes, but not in astrocytes. MLKL activation was detected in astrocytes and neurons but not endothelium or pericytes. Compared with WT controls, RIPK1 kinase-dead (

Indexed as

NecrosisAnimalsBehavior, AnimalBlood-Brain BarrierCell Membrane PermeabilityCerebral HemorrhageEdemaInflammationMaleMiceMice, KnockoutNeuronsProtein KinasesReceptor-Interacting Protein Serine-Threonine KinasesMLKL protein, mouseProtein KinasesReceptor-Interacting Protein Serine-Threonine KinasesRipk1 protein, mouseintracerebral hemorrhagemicemixed lineage kinase like (MLKL).necroptosisreceptor-interacting protein kinase-1 (RIPK1)

Identifiers

PMID33210566
PMCPMC8221773
OpenAlexW3101671924

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.