Evidence map›Paper›PMID 33210468›Full record

Trial reportMolecular systems biology2020

Gene expression profiling reveals insights into infant immunological and febrile responses to group B meningococcal vaccine.

Daniel O'Connor, Marta Valente Pinto, Dylan Sheerin, Adriana Tomic, Ruth E Drury, Samuel Channon-Wells, Ushma Galal, Christina Dold, Hannah Robinson, Simon Kerridge and 8 more

Open access · goldAbstract readRandomized Controlled TrialValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Molecular systems biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
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  8. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 3 countries.

Daniel O'ConnorDepartment of Paediatrics, University of Oxford, Oxford, UK.ORCID 0000-0002-6902-9886
Marta Valente PintoDepartment of Paediatrics, University of Oxford, Oxford, UK.
Dylan SheerinDepartment of Paediatrics, University of Oxford, Oxford, UK.ORCID 0000-0001-9456-5712
Adriana TomicDepartment of Paediatrics, University of Oxford, Oxford, UK.
Ruth E DruryDepartment of Paediatrics, University of Oxford, Oxford, UK.
Samuel Channon-WellsDepartment of Paediatrics, University of Oxford, Oxford, UK.ORCID 0000-0002-8166-8680
Ushma GalalNuffield Department of Primary Health Care, Clinical Trials Unit, University of Oxford, Oxford, UK.
Christina DoldDepartment of Paediatrics, University of Oxford, Oxford, UK.
Hannah RobinsonDepartment of Paediatrics, University of Oxford, Oxford, UK.
Simon KerridgeDepartment of Paediatrics, University of Oxford, Oxford, UK.
Emma PlestedDepartment of Paediatrics, University of Oxford, Oxford, UK.
Harri HughesDepartment of Paediatrics, University of Oxford, Oxford, UK.
Lisa StockdaleDepartment of Paediatrics, University of Oxford, Oxford, UK.
Manish SadaranganiDepartment of Pediatrics, University of British Columbia, Vancouver, Canada.
Matthew D SnapeDepartment of Paediatrics, University of Oxford, Oxford, UK.
Christine S RollierDepartment of Paediatrics, University of Oxford, Oxford, UK.ORCID 0000-0002-9712-8080
Michael LevinDivision of Infectious Diseases, Department of Medicine, Imperial College London, London, UK.
Andrew J PollardDepartment of Paediatrics, University of Oxford, Oxford, UK.
University of Oxford · GBImperial College London · GBUniversity of British Columbia · CA

Funding

Department of HealthMedical Research Council MR/M007693/1Wellcome TrustWellcome Trust 090532/Z/09/Z
6 · The paper itself

Abstract

Neisseria meningitidis is a major cause of meningitis and septicaemia. A MenB vaccine (4CMenB) was licensed by the European Medicines Agency in January 2013. Here we describe the blood transcriptome and proteome following infant immunisations with or without concomitant 4CMenB, to gain insight into the molecular mechanisms underlying post-vaccination reactogenicity and immunogenicity. Infants were randomised to receive control immunisations (PCV13 and DTaP-IPV-Hib) with or without 4CMenB at 2 and 4 months of age. Blood gene expression and plasma proteins were measured prior to, then 4 h, 24 h, 3 days or 7 days post-vaccination. 4CMenB vaccination was associated with increased expression of ENTPD7 and increased concentrations of 4 plasma proteins: CRP, G-CSF, IL-1RA and IL-6. Post-vaccination fever was associated with increased expression of SELL, involved in neutrophil recruitment. A murine model dissecting the vaccine components found the concomitant regimen to be associated with increased gene perturbation compared with 4CMenB vaccine alone with enhancement of pathways such as interleukin-3, -5 and GM-CSF signalling. Finally, we present transcriptomic profiles predictive of immunological and febrile responses following 4CMenB vaccine.

Indexed as

AnimalsBlood Chemical AnalysisDiphtheria-Tetanus-Pertussis VaccineFemaleFeverGene Expression ProfilingHaemophilus VaccinesHost-Pathogen InteractionsHumansImmunityIncidenceInfantMaleMeningococcal InfectionsMeningococcal VaccinesMice13-valent pneumococcal vaccinediphtheria-tetanus-five component acellular pertussis-inactivated poliomyelitis -Haemophilus influenzae type b conjugate vaccineDiphtheria-Tetanus-Pertussis VaccineHaemophilus VaccinesMeningococcal VaccinesPneumococcal VaccinesPoliovirus Vaccine, InactivatedProteomeVaccines, Conjugatepaediatricsproteomicssystems biologytranscriptomicsvaccines

Identifiers

PMID33210468
PMCPMC7674973
OpenAlexW3105842719

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.