Evidence map›Paper›PMID 33210397›Full record

ArticleHaemophilia : the official journal of the World Federation of Hemophilia2021

Real-world data of immune tolerance induction using recombinant factor VIII Fc fusion protein in patients with severe haemophilia A with inhibitors at high risk for immune tolerance induction failure: A follow-up retrospective analysis.

Manuel Carcao, Amy Shapiro, Nina Hwang, Steven Pipe, Sanjay Ahuja, Ken Lieuw, Janice M Staber, Mark Belletrutti, Haowei Linda Sun, Hilda Ding and 8 more

Open access · hybridAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Haemophilia : the official journal of the World Federation of Hemophilia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 14 institutions in 2 countries.

Manuel CarcaoThe Hospital for Sick Children, Toronto, ON, Canada.ORCID https://orcid.org/0000-0001-5350-1763
Amy ShapiroIndiana Hemophilia & Thrombosis Center, Inc, Indianapolis, IN, USA.ORCID https://orcid.org/0000-0003-2821-7159
Nina HwangCenter For Inherited Blood Disorders, Orange, CA, USA.
Steven PipeUniversity of Michigan, Ann Arbor, MI, USA.ORCID https://orcid.org/0000-0003-2558-2089
Sanjay AhujaUniversity Hospitals Rainbow Babies & Children's Hospital, Cleveland, OH, USA.
Ken LieuwWalter Reed National Military Medical Center, Bethesda, MD, USA.
Janice M StaberUniversity of Iowa Stead Family Children's Hospital, Iowa City, IA, USA.ORCID https://orcid.org/0000-0002-2738-4206
Mark BelletruttiUniversity of Alberta Stollery Children's Hospital, Edmonton, AB, Canada.
Haowei Linda SunUniversity of Alberta Hospital, Edmonton, AB, Canada.ORCID https://orcid.org/0000-0002-0205-9722
Hilda DingRady Children's Hospital, San Diego, CA, USA.
Michael WangHemophilia and Thrombosis Center, University of Colorado, Aurora, CO, USA.ORCID https://orcid.org/0000-0001-9289-4862
Victoria PriceIWK Health Centre, Halifax, NS, Canada.
MacGregor SteeleAlberta Children's Hospital, Calgary, AB, Canada.
Elisa TsaoSanofi, Waltham, MA, USA.
Jing FengSanofi, Waltham, MA, USA.
Zahra Al-KhateebTrinity Partners LLC, Waltham, MA, USA.
Jennifer DumontSanofi, Cambridge, MA, USA.
Nisha JainSanofi, Cambridge, MA, USA.
Sanofi (United States) · USAlberta Children's Hospital · CAAlberta Hospital Edmonton · CACenter for Inherited Blood Disorders · USHospital for Sick Children · CAIndiana Hemophilia and Thrombosis Center · USIzaak Walton Killam Health Centre · CARady Children's Hospital-San Diego · USRainbow Babies & Children's Hospital · USUniversity of Alberta · CAUniversity of Colorado Anschutz Medical Campus · USUniversity of Iowa Stead Family Children’s Hospital · USUniversity of Michigan · USWalter Reed National Military Medical Center · US

Funding

Sanofi
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Factor VIIIHemophilia AFollow-Up StudiesHumansImmune ToleranceRetrospective StudiesFactor VIIIhaemophilia Aimmune tolerance inductioninhibitorrecombinant factor VIII Fc fusion proteinrescue therapyretrospective chart review

Identifiers

PMID33210397
PMCPMC8243250
OpenAlexW3098703056

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.