Evidence map›Paper›PMID 33210255›Full record

ArticleMolecular biology reports2020

Effect of atorvastatin on AGEs-induced injury of cerebral cortex via inhibiting NADPH oxidase -NF-κB pathway in ApoE

Zhenhan Li, Peiye Yang, Bo Feng

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Zhenhan LiDepartment of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Peiye YangDepartment of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Bo FengDepartment of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. fengbodfyy@tongji.edu.cn.
Shanghai East Hospital · CN

Funding

Pudong Health and Family Planning Commission of Shanghai PWZzk2017-12
6 · The paper itself

Abstract

Advanced glycation end products (AGEs) are a group of modified proteins and/or lipids with damaging potential. AGEs-RAGE pathway plays a critical role to induce neurodegenerative encephalopathy. Statins can reduce the expression of AGEs-induced AGEs receptor (RAGE) in the aorta. It is not clear whether statins have potential benefits on AGEs-induced cognitive impairment. In this study, the effects of atorvastatin (ATV) on inflammation and oxidation stress in the cerebral cortex were investigated, and the underlying mechanisms were explored. Apolipoprotein E (ApoE)

Indexed as

Amyloid beta-PeptidesAnimalsAnticholesteremic AgentsApolipoproteins EAtorvastatinCerebral CortexDiet, High-FatGene Expression RegulationGlycation End Products, AdvancedImmunohistochemistryInflammationMaleMiceMice, KnockoutNADPH OxidasesNeuronsAger protein, mousealagebriumAmyloid beta-PeptidesAnticholesteremic AgentsApoe protein, mouseApolipoproteins EAtorvastatinGlycation End Products, AdvancedNADPH Oxidasesneutrophil cytosolic factor 1Receptor for Advanced Glycation End ProductsRela protein, mouseThiazolesTranscription Factor RelAAgesAtorvastatinCentral nervous systemRAGE

Identifiers

PMID33210255
OpenAlexW3100528295

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.