Evidence map›Paper›PMID 33210245›Full record

ArticleCerebellum (London, England)2021

Functional Alterations in Cerebellar Functional Connectivity in Anxiety Disorders.

Yoon Ji Lee, Xavier Guell, Nicholas A Hubbard, Viviana Siless, Isabelle R Frosch, Mathias Goncalves, Nicole Lo, Atira Nair, Satrajit S Ghosh, Stefan G Hofmann and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebellum (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
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  8. The Functional Anatomy of Nociception: Effective Connectivity in Chronic Pain and Placebo Response.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 1 country.

Yoon Ji LeeDepartment of Psychology, ISEC 672D, Northeastern University, Boston, MA, 02115, USA.ORCID http://orcid.org/0000-0001-7295-5672
Xavier GuellMassachusetts General Hospital, Boston, MA, USA.
Nicholas A HubbardUniversity of Nebraska-Lincoln, Lincoln, NE, USA.
Viviana SilessAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA.
Isabelle R FroschMassachusetts Institute of Technology, Cambridge, MA, USA.
Mathias GoncalvesMassachusetts Institute of Technology, Cambridge, MA, USA.
Nicole LoMassachusetts Institute of Technology, Cambridge, MA, USA.
Atira NairDepartment of Psychology, ISEC 672D, Northeastern University, Boston, MA, 02115, USA.
Satrajit S GhoshAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA.
Stefan G HofmannBoston University, Boston, MA, USA.
Randy P AuerbachColumbia University, New York, NY, USA.
Diego A PizzagalliMcLean Hospital, Belmont, MA, USA.
Anastasia YendikiAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA.
John D E GabrieliMassachusetts Institute of Technology, Cambridge, MA, USA.
Susan Whitfield-GabrieliDepartment of Psychology, ISEC 672D, Northeastern University, Boston, MA, 02115, USA.
Sheeba Arnold AnteraperDepartment of Psychology, ISEC 672D, Northeastern University, Boston, MA, 02115, USA. s.anteraper@northeastern.edu.
Massachusetts Institute of Technology · USNortheastern University · USHarvard University · USMassachusetts General Hospital · USColumbia University · USMcLean Hospital · USUniversity of Nebraska–Lincoln · US

Funding

Connectomes Related to Anxiety and Depression in AdolescentsU01MH108168 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIELI, JOHN, WHITFIELD-GABRIELI, SUSAN · 2015 to 2019
$4.6M
Imaging the neurodevelopmental trajectory of depression and anxiety disorders with HCP protocolsR56MH121426 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI WHITFIELD-GABRIELI, SUSAN, YENDIKI, ANASTASIA · 2020 to 2020
$1.2M
NIMH NIH HHS R56 MH121426NIMH NIH HHS U01 MH108168NIMH NIH HHS U01MH108168-01
6 · The paper itself

Abstract

Adolescents with anxiety disorders exhibit excessive emotional and somatic arousal. Neuroimaging studies have shown abnormal cerebral cortical activation and connectivity in this patient population. The specific role of cerebellar output circuitry, specifically the dentate nuclei (DN), in adolescent anxiety disorders remains largely unexplored. Resting-state functional connectivity analyses have parcellated the DN, the major output nuclei of the cerebellum, into three functional territories (FTs) that include default-mode, salience-motor, and visual networks. The objective of this study was to understand whether FTs of the DN are implicated in adolescent anxiety disorders. Forty-one adolescents (mean age 15.19 ± 0.82, 26 females) with one or more anxiety disorders and 55 age- and gender-matched healthy controls completed resting-state fMRI scans and a self-report survey on anxiety symptoms. Seed-to-voxel functional connectivity analyses were performed using the FTs from DN parcellation. Brain connectivity metrics were then correlated with State-Trait Anxiety Inventory (STAI) measures within each group. Adolescents with an anxiety disorder showed significant hyperconnectivity between salience-motor DN FT and cerebral cortical salience-motor regions compared to controls. Salience-motor FT connectivity with cerebral cortical sensorimotor regions was significantly correlated with STAI-trait scores in HC (R

Indexed as

AdolescentAnxiety DisordersBrain MappingCerebellumFemaleHumansMagnetic Resonance ImagingMaleMovementNerve NetNeuropsychological TestsSelf ReportAnxietyCerebellumDentate nucleusMotor networkSalience network

Identifiers

PMID33210245
PMCPMC8213597
OpenAlexW3099683143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.