Evidence map›Paper›PMID 33210205›Full record

ArticleMolecular neurobiology2021

Alteration of miRNA Biogenesis Regulating Proteins in the Human Microglial Cell Line HMC-3 After Ischemic Stress.

Clara Voelz, Pardes Habib, Stefan Köberlein, Cordian Beyer, Alexander Slowik

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Stress Granules and Acute Ischemic Stroke: Beyond mRNA Translation.International journal of molecular sciences · 2022
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Clara VoelzInstitute of Neuroanatomy, Medical Faculty, RWTH Aachen University, 52074, Aachen, Germany.ORCID https://orcid.org/0000-0003-3090-6682
Pardes HabibDepartment of Neurology, Medical Faculty, RWTH Aachen University, Aachen, Germany.ORCID https://orcid.org/0000-0002-5771-216X
Stefan KöberleinInstitute of Neuroanatomy, Medical Faculty, RWTH Aachen University, 52074, Aachen, Germany.
Cordian BeyerInstitute of Neuroanatomy, Medical Faculty, RWTH Aachen University, 52074, Aachen, Germany.ORCID https://orcid.org/0000-0003-3926-2553
Alexander SlowikInstitute of Neuroanatomy, Medical Faculty, RWTH Aachen University, 52074, Aachen, Germany. aslowik@ukaachen.de.ORCID http://orcid.org/0000-0001-9907-2263
RWTH Aachen University · DEBrain (Germany) · DE

Funding

Medizinische Fakultät, RWTH Aachen University START-117/18
6 · The paper itself

Abstract

MicroRNAs (miRNA) are small noncoding sequences that control apoptosis, proliferation, and neuroinflammatory pathways in microglia cells. The expression of distinct miRNAs is altered after ischemia in the brain. Only minor information is available about the biogenesis and maturation of miRNAs after ischemia. We aimed at examining the impact of oxygen-glucose deprivation (OGD) and hydrogen peroxide (H

Indexed as

Argonaute ProteinsBrain IschemiaCell LineDNA HelicasesGene Expression RegulationGlucoseHumansHydrogen PeroxideMicrogliaMicroRNAsModels, BiologicalOxidative StressOxygenPoly-ADP-Ribose Binding ProteinsRibonuclease IIIRNA HelicasesAGO2 protein, humanArgonaute ProteinsDNA HelicasesDROSHA protein, humanG3BP1 protein, humanGlucoseHydrogen PeroxideMicroRNAsOxygenPoly-ADP-Ribose Binding ProteinsRibonuclease IIIRNA HelicasesRNA Recognition Motif ProteinsAGO2Hydrogen peroxideHypoxiaIschemiamiRNA biogenesisOGD

Identifiers

PMID33210205
OpenAlexW3103066089

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.