Evidence map›Paper›PMID 33210187›Full record

ArticleNeuroscience bulletin2021

Elevated L-lactate Promotes Major Cellular Pathologies Associated with Neurodegenerative Diseases.

Andrew D Chapp, Jessica E Behnke, Kyle M Driscoll, Taija Hahka, Zoe LaLonde, Zhiying Shan, Qing-Hui Chen

Open access · greenAbstract readLetter
In one paragraph

Article in Neuroscience bulletin, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Lactate and cognition: a dual modulator.Frontiers in molecular neuroscience · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Andrew D Chapp *Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, MI, 49931, USA. achapp@umn.edu.
Jessica E Behnke *Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, MI, 49931, USA.
Kyle M DriscollDepartment of Biological Sciences, Michigan Technological University, Houghton, MI, 49931, USA.
Taija HahkaDepartment of Biological Sciences, Michigan Technological University, Houghton, MI, 49931, USA.
Zoe LaLondeDepartment of Biological Sciences, Michigan Technological University, Houghton, MI, 49931, USA.
Zhiying ShanDepartment of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, MI, 49931, USA.
Qing-Hui ChenDepartment of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, MI, 49931, USA. qinghuic@mtu.edu.ORCID 0000-0002-1639-5292
Michigan Technological University · US

Funding

Neural Mechanism of Sympathetic Activation in Heart FailureR15HL145655 · NHLBI · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI CHEN, QING-HUI H · 2019 to 2019
$459k
ER stress and reduced SK channel function in PVN in rats with high salt intakeR15HL122952 · NHLBI · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI CHEN, QING-HUI H · 2015 to 2015
$459k
NHLBI NIH HHS R15 HL122952NHLBI NIH HHS R15 HL145655
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Neurodegenerative DiseasesHumansLactatesLactates

Identifiers

PMID33210187
PMCPMC7955001
OpenAlexW3105385864

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.