ArticleBrain communications2020
Analysis of brain atrophy and local gene expression in genetic frontotemporal dementia.
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Article in Brain communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
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- Evidence for divergent cortical organisation in Parkinson's disease and Lewy Body Dementia.Nature communications · 2025Article
- Progranulin deficiency in the brain: the interplay between neuronal and non-neuronal cells.Translational neurodegeneration · 2025Review
- Beyond the usual suspects: multi-factorial computational models in the search for neurodegenerative disease mechanisms.Translational psychiatry · 2024Review
- Frontotemporal lobar degeneration targets brain regions linked to expression of recently evolved genes.Brain : a journal of neurology · 2024Article
- Molecular basis underlying default mode network functional abnormalities in postpartum depression with and without anxiety.Human brain mapping · 2024Article
- Entorhinal cortex astrocytic atrophy in human frontotemporal dementia.Brain structure & function · 2024Article
- Distinctive whole-brain cell types predict tissue damage patterns in thirteen neurodegenerative conditions.eLife · 2024Article
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- Genetic topography and cortical cell loss in Huntington's disease link development and neurodegeneration.Brain : a journal of neurology · 2023Article
- FTLD targets brain regions expressing recently evolved genes.medRxiv : the preprint server for health sciences · 2023Article
- Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight.Nature reviews. Neuroscience · 2023Review
- Neurocognitive patterns across genetic levels in behavioral variant frontotemporal dementia: a multiple single cases study.BMC neurology · 2022Article
- Impact of APOE genotype on prion-type propagation of tauopathy.Acta neuropathologica communications · 2022Article
- Review
- Mitochondrial disease manifestations in relation to transcriptome location and function.Molecular genetics and metabolism · 2022Article
- Posterior cingulate cortex reveals an expression profile of resilience in cognitively intact elders.Brain communications · 2022Article
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- Pathophysiological Underpinnings of Extra-Motor Neurodegeneration in Amyotrophic Lateral Sclerosis: New Insights From Biomarker Studies.Frontiers in neurology · 2021Review
Corrections and comments
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Authors and funding
36 authors at 20 institutions in 9 countries.
Andre AltmannCentre of Medical Image Computing, Department of Medical Physics, University College London, London, UK.
David M CashCentre of Medical Image Computing, Department of Medical Physics, University College London, London, UK.
Martina BocchettaDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London, UK.
Carolin HellerDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London, UK.
Regina ReynoldsDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London, UK.
Katrina MooreDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London, UK.
Rhian S ConveryDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London, UK.
David L ThomasNeuroimaging Analysis Centre, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, UK.
John C van SwietenDepartment of Neurology, Erasmus Medical Centre, Rotterdam, Netherlands.
Fermin MorenoCognitive Disorders Unit, Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa, Spain.
Raquel Sanchez-ValleAlzheimer's disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Barcelona, Spain.
Barbara BorroniCentre for Neurodegenerative Disorders, Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Robert LaforceClinique Interdisciplinaire de Mémoire, Département des Sciences Neurologiques, CHU de Québec, and Faculté de Médecine, Université Laval, QC, Canada.
Mario MasellisSunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto, Canada.
Maria Carmela TartagliaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada.
Caroline GraffCenter for Alzheimer Research, Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Bioclinicum, Karolinska Institutet, Solna, Sweden.
Daniela GalimbertiUniversity of Milan, Centro Dino Ferrari, Milan, Italy.
James B RoweDepartment of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge, UK.
Elizabeth FingerDepartment of Clinical Neurological Sciences, University of Western Ontario, London, Ontario Canada.
Matthis SynofzikDepartment of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany.
Rik VandenbergheLaboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium.
Alexandre de MendonçaLaboratory of Neurosciences, Faculty of Medicine, University of Lisbon, Lisbon, Portugal.
Fabrizio TagliaviniFondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta, Milano, Italy.
Isabel SantanaUniversity Hospital of Coimbra (HUC), Neurology Service, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Simon DucharmeDepartment of Psychiatry, McGill University Health Centre, McGill University, Montreal, Québec, Canada.
Chris R ButlerNuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford, Oxford, UK.
Alex GerhardDivision of Neuroscience and Experimental Psychology, Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.
Johannes LevinNeurologische Klinik, Ludwig-Maximilians-Universität München, Munich, Germany.
Adrian DanekNeurologische Klinik, Ludwig-Maximilians-Universität München, Munich, Germany.
Giovanni FrisoniInstituto di Recovero e Cura a Carattere Scientifico Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Roberta GhidoniMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Sandro SorbiDepartment of Neuroscience, Psychology, Drug Research, and Child Health, University of Florence, Florence, Italy.
Markus OttoDepartment of Neurology, University of Ulm, Ulm.
Mina RytenDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London, UK.
Jonathan D RohrerDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London, UK.
Genetic FTD Initiative, GENFI
NIHR Queen Square Dementia Biomedical Research Unit · GBCentro San Giovanni di Dio Fatebenefratelli · ITGerman Center for Neurodegenerative Diseases · DEBiogipuzkoa Health Research Institute · ESDon Carlo Gnocchi Foundation · ITErasmus University Rotterdam · NLFondazione IRCCS Istituto Neurologico Carlo Besta · ITKarolinska University Hospital · SEKU Leuven · BELudwig-Maximilians-Universität München · DEMontreal Neurological Institute and Hospital · CASunnybrook Health Science Centre · CAUniversitat de Barcelona · ESUniversität Ulm · DEUniversité Laval · CAUniversity College London · GBUniversity of Brescia · ITUniversity of Cambridge · GBUniversity of Coimbra · PTUniversity of Lisbon · PT
Funding
Medical Research Council MR/J009482/1Medical Research Council MR/L016311/1Medical Research Council MR/M008525/1Medical Research Council MR/M023664/1Medical Research Council MR/N008324/1Medical Research Council MR/T046015/1
Abstract
Frontotemporal dementia is a heterogeneous neurodegenerative disorder characterized by neuronal loss in the frontal and temporal lobes. Despite progress in understanding which genes are associated with the aetiology of frontotemporal dementia, the biological basis of how mutations in these genes lead to cell loss in specific cortical regions remains unclear. In this work we combined gene expression data for 16,772 genes from the Allen Institute for Brain Science atlas with brain maps of gray matter atrophy in symptomatic
Indexed as
astrocytesatrophyFrontotemporal dementiagene expressionimaging genetics
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.