Evidence map›Paper›PMID 33210039›Full record

ArticleBrain circulation

Frequency of thrombolytic targets in stroke patients presenting in an extended time window.

Parisa Heidari, Sarah Blayney, Jarrhett Butler, Emi Hitomi, Marie Luby, Richard Leigh

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Parisa HeidariNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Sarah BlayneyNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Jarrhett ButlerNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Emi HitomiNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Marie LubyNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Richard LeighNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
National Institutes of Health · USNational Institute of Neurological Disorders and Stroke · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of this study was to determine the proportion of stroke patients presenting in an extended time window who have a thrombolytic treatment target.

backgroundPatients presenting up to 24 h after stroke onset have been found to have penumbral tissue on multimodal imaging. Stroke patients presenting in this extended time window without a large vessel occlusion (LVO) may benefit from reperfusion therapy using thrombolysis.

methodsPatients seen at our institutions from 2011 through 2015 were reviewed to identify those who presented >4 h and <24 h from last seen normal (LSN) and did not receive acute treatment. Magnetic resonance imaging (MRI) scans were used to dichotomize patients using a diffusion-perfusion mismatch ratio of 1.2.

resultsDuring the study period, 3469 patients were evaluated by our stroke service, with 893 seen 4-24 h from LSN who were not treated. MRI was performed with diffusion and perfusion imaging in 439 patients, of whom 26 were excluded due to hemorrhage and 37 were excluded due to LVO. This left 376 patients who potentially could have been treated with thrombolysis in an extended time window and were included in the analysis. Of these, 156 (42%) demonstrated a mismatch ratio >1.2. Patients with a mismatch presented earlier (

conclusionsAlmost half of the patients presenting 4-24 h from LSN had a target for thrombolysis in our study. Multimodal imaging may be able to expand the population of treatable stroke patients given the results of recent clinical trials.

Indexed as

Extended time windowmagnetic resonance imagingpenumbral imagingthrombolysis

Identifiers

PMID33210039
PMCPMC7646384
OpenAlexW3089356704

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.