Evidence map›Paper›PMID 33210027›Full record

ArticleBioactive materials2021

Combination of magnesium ions and vitamin C alleviates synovitis and osteophyte formation in osteoarthritis of mice.

Hao Yao, Jiankun Xu, Jiali Wang, Yifeng Zhang, Nianye Zheng, Jiang Yue, Jie Mi, Lizhen Zheng, Bingyang Dai, Wenhan Huang and 6 more

Open access · goldAbstract read
In one paragraph

Article in Bioactive materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 94 citations in OpenAlex.

  1. Article
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  7. The research progress of α-ketoglutarate in osteoarthritis.Biochemistry and biophysics reports · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Hao YaoMusculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Jiankun XuMusculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Jiali WangSchool of Biomedical Engineering, Sun Yat-sen University, Guangzhou, PR China.
Yifeng ZhangSchool of Life Science and Technology, Shanghai Tech University, Shanghai, PR China.
Nianye ZhengMusculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Jiang YueMusculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Jie MiMusculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Lizhen ZhengMusculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Bingyang DaiMusculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Wenhan HuangMusculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Shuhang YungMusculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Peijie HuDepartment of Biomedical Engineering, Polytechnic University of Hong Kong, Hong Kong, China.
Yechun RuanDepartment of Biomedical Engineering, Polytechnic University of Hong Kong, Hong Kong, China.
Qingyun XueDepartment of Orthopedics, Beijing Hospital, No. 5th Clinical Medical Collage, Health Science Center, Peking University, Beijing, PR China.
Kiwai HoMusculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Ling QinMusculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Chinese University of Hong Kong · HKHong Kong Polytechnic University · HKPeking University · CNShanghaiTech University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe previously demonstrated that magnesium ions (Mg MATERIAL AND

methodsAnterior cruciate ligament transection with partial medial meniscectomy induced mice OA model were randomly received intra-articular injection of either saline, MgCl

resultsMg

conclusionsIntra-articular administration of Mg

Indexed as

CartilageInflammationMagnesiumOsteoarthritisOsteophyteVitamin C

Identifiers

PMID33210027
PMCPMC7658330
OpenAlexW3103508357

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.