Evidence map›Paper›PMID 33209599›Full record

ArticleTranslational lung cancer research2020

KRAS G12C mutations in Asia: a landscape analysis of 11,951 Chinese tumor samples.

Herbert Ho-Fung Loong, Nan Du, Chunyan Cheng, Hanqing Lin, Jian Guo, Gen Lin, Mingjiang Li, Tao Jiang, Zhihua Shi, Yanzhi Cui and 7 more

Open access · diamondAbstract read
In one paragraph

Article in Translational lung cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Pharmacogenomics in oncology: mutation-targeted therapy and biomarker integration in non-small cell lung cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  4. Article
  5. Article
  6. Emerging Therapeutic Landscapes for KRAS-Mutant Pancreatic Ductal Adenocarcinoma: Beyond the "Undruggable" Paradigm.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Targeting KRASDrugs · 2024
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 1 country.

Herbert Ho-Fung LoongDepartment of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong SAR, China.
Nan DuDepartment of Oncology, First Affiliated Hospital, Chinese PLA General Hospital, Beijing, China.
Chunyan ChengOrigiMed, Shanghai, China.
Hanqing LinOrigiMed, Shanghai, China.
Jian GuoDivision of Thoracic Surgery, Tianjin First Central Hospital, Tianjin, China.
Gen LinDepartment of Thoracic Oncology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, China.
Mingjiang LiDivision of Thoracic Surgery, Tianjin First Central Hospital, Tianjin, China.
Tao JiangDivision of Thoracic Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Zhihua ShiDivision of Thoracic Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Yanzhi CuiMedical Oncology, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Xianfeng JinDivision of Thoracic Surgery, the Affiliated Hospital of Qingdao University, Qingdao, China.
Jicheng YaoOrigiMed, Shanghai, China.
Yutong XingOrigiMed, Shanghai, China.
Ming YaoOrigiMed, Shanghai, China.
Kai WangOrigiMed, Shanghai, China.
Tony S K MokDepartment of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong SAR, China.
Lunxu LiuDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.
Unimed Medical Institute · CNChinese University of Hong Kong · CNHebei Medical University · CNTianjin First Center Hospital · CNAffiliated Hospital of Qingdao University · CNFirst Affiliated Hospital of Chinese PLA General Hospital · CNFourth Hospital of Hebei Medical University · CNFujian Provincial Cancer Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKirsten rat sarcoma vial oncogene (

methodsSequencing data of 11,951 tumor samples collected from 11/2016 to 7/2019 from multiple centres in China were analyzed for

resultsKRAS mutations were identified in 1978 (16.6%) patient samples. Specifically,

conclusionsThe overall incidence of

Indexed as

actionable alterationco-aberrationKRAS G12Cpathway analysissmoking status

Identifiers

PMID33209599
PMCPMC7653137
OpenAlexW3081154089

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.