Evidence map›Paper›PMID 33209323›Full record

ArticleIUCrJ2020

Cortisone and cortisol break hydrogen-bonding rules to make a drug-prodrug solid solution.

Vivek Verma, Simone Bordignon, Michele R Chierotti, Monica Lestari, Kieran Lyons, Luis Padrela, Kevin M Ryan, Matteo Lusi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IUCrJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vivek VermaDepartment of Chemistry and Bernal Institute, University of Limerick, Limerick, Ireland.
Simone BordignonDipartimento di Chimica, Università di Torino, Torino, Italy.
Michele R ChierottiDipartimento di Chimica, Università di Torino, Torino, Italy.
Monica LestariDepartment of Chemistry and Bernal Institute, University of Limerick, Limerick, Ireland.
Kieran LyonsDepartment of Chemistry and Bernal Institute, University of Limerick, Limerick, Ireland.
Luis PadrelaDepartment of Chemistry and Bernal Institute, University of Limerick, Limerick, Ireland.ORCID https://orcid.org/0000-0002-8632-2320
Kevin M RyanDepartment of Chemistry and Bernal Institute, University of Limerick, Limerick, Ireland.
Matteo LusiDepartment of Chemistry and Bernal Institute, University of Limerick, Limerick, Ireland.ORCID https://orcid.org/0000-0002-9067-7802

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multidrug products enable more effective therapies and simpler administration regimens, provided that a stable formulation is prepared, with the desired composition. In this view, solid solutions have the advantage of combining the stability of a single crystalline phase with the potential of stoichiometry variation of a mixture. Here a drug-prodrug solid solution of cortisone and cortisol (hydrocortisone) is described. Despite the structural differences of the two components, the new phase is obtained both from solution and by supercritical CO

Indexed as

assisted spray dryingcortisonehydrocortisonehydrogen bondingmixed crystalsmultidrug formulationspharmaceutical solidssolid solutionssteroids

Identifiers

PMID33209323
PMCPMC7642785

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.