Evidence map›Paper›PMID 33209322›Full record

ArticleIUCrJ2020

Recovery of undamaged electron-density maps in the presence of damage-induced partial coherence in single-particle imaging.

Alexander Kozlov, Timur E Gureyev, David M Paganin, Andrew V Martin, Carl Caleman, Harry M Quiney

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IUCrJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexander KozlovARC Centre of Excellence in Advanced Molecular Imaging, School of Physics, University of Melbourne, Parkville, Victoria 3010, Australia.
Timur E GureyevARC Centre of Excellence in Advanced Molecular Imaging, School of Physics, University of Melbourne, Parkville, Victoria 3010, Australia.ORCID https://orcid.org/0000-0002-1103-0649
David M PaganinSchool of Physics and Astronomy, Monash University, Clayton, Victoria 3800, Australia.ORCID https://orcid.org/0000-0002-7758-7140
Andrew V MartinARC Centre of Excellence in Advanced Molecular Imaging, School of Physics, University of Melbourne, Parkville, Victoria 3010, Australia.ORCID https://orcid.org/0000-0002-4958-2609
Carl CalemanDepartment of Physics and Astronomy, Uppsala University, PO Box 516, SE-751 20 Uppsala, Sweden.
Harry M QuineyARC Centre of Excellence in Advanced Molecular Imaging, School of Physics, University of Melbourne, Parkville, Victoria 3010, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resolving the electronic structure of single biological molecules in their native state was among the primary motivations behind X-ray free-electron lasers. The ultra-short pulses they produce can outrun the atomic motion induced by radiation damage, but the electronic structure of the sample is still significantly modified from its original state. This paper explores the decoherence of the scattered signal induced by temporal evolution of the electronic structure in the sample molecule. It is shown that the undamaged electron density of a single-molecule sample can often be retrieved using only the two most occupied modes from the coherent mode decomposition of the partially coherent diffraction fluence.

Indexed as

partial coherenceradiation damagesingle-particle imagingXFELs

Identifiers

PMID33209322
PMCPMC7642773

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.