Evidence map›Paper›PMID 33209036›Full record

ArticleOncoTargets and therapy2020

Functional Implication of Exosomal miR-217 and miR-23b-3p in the Progression of Prostate Cancer.

Cuixing Zhou, Yimeng Chen, Xiaozhou He, Zhuojun Zheng, Dong Xue

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in OncoTargets and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Exosomal ncRNAs in reproductive cancers†.Biology of reproduction · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Cuixing ZhouDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, People's Republic of China.
Yimeng ChenDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, People's Republic of China.
Xiaozhou HeDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, People's Republic of China.
Zhuojun ZhengDepartment of Hematology, The Third Affiliated Hospital of Soochow University, Changzhou, People's Republic of China.ORCID 0000-0003-3277-9998
Dong XueDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, People's Republic of China.
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe microRNA expression profile of plasma exosomes in prostate cancer (PCa) is of critical importance in the disease exploration. This study aimed to explore the clinical application of exosomal miRNAs as biomarkers for PCa.

methodsExosome-like vesicles of PCa patients and healthy controls were purified by differential centrifugation. The purified vesicles within the ranges of 50 and 100 nm were classified as exosomes according to the results of transmission electron microscopy and Western blot. Both, in vitro and in vivo, validations were performed by small RNA sequencing, CCK8, RT-qPCR, flow cytometry, Western blot, transwell and immunofluorescent staining assays.

resultsHigh-throughput sequencing identified that 94 miRNAs were differentially expressed in PCa patients in comparison with healthy controls (

conclusionThis study identified the dysregulated expression of exosomal miRNAs in PCa patients, including miR-217 and miR-23b-3p, by validating their function on proliferation and invasion in PCa cells. This regulation may have been affected by the epithelial-mesenchymal transition process, suggesting that they can be used as potential targets in the diagnosis and treatment of PCa.

Indexed as

exosomemiR-217miR-23b-3pprostate cancer

Identifiers

PMID33209036
PMCPMC7670263
OpenAlexW3104344865

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.