Evidence map›Paper›PMID 33208945›Full record

ArticleNature2020

Assembly of synaptic active zones requires phase separation of scaffold molecules.

Nathan A McDonald, Richard D Fetter, Kang Shen

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 103 papers.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Liquid-liquid phase separation in neural development.Cellular and molecular life sciences : CMLS · 2026
    Review
  7. Article
  8. ImmatureProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Review
  10. Review
  11. Review
  12. ImmaturebioRxiv : the preprint server for biology · 2025
    Article
  13. CASKIN2 mediates PTPσ-orchestrated transsynaptic mechanisms at excitatory synapses.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Article
  15. Synaptobrevin-2 disease variants reveal spatial constraints within the presynaptic active zone.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Article
  17. Biogenesis and reformation of synaptic vesicles.The Journal of physiology · 2025
    Review
  18. Review
  19. Article
  20. Review

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Nathan A McDonaldDepartment of Biology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-2716-3881
Richard D FetterHoward Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-1558-100X
Kang ShenDepartment of Biology, Stanford University, Stanford, CA, USA. kangshen@stanford.edu.ORCID http://orcid.org/0000-0003-4059-8249

Funding

Mechanisms of synaptic specificity in C. elegansR37NS048392 · NINDS · STANFORD UNIVERSITY · PI SHEN, KANG · 2015 to 2019
$2.0M
Howard Hughes Medical InstituteNINDS NIH HHS R37 NS048392
6 · The paper itself

Abstract

The formation of synapses during neuronal development is essential for establishing neural circuits and a nervous system

Indexed as

Amino Acid MotifsAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsMutant ProteinsMutationNeural PathwaysSynapsesCaenorhabditis elegans Proteinselks-1 protein, C elegansIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsMutant ProteinsSYD-2 protein, C elegans

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.