Evidence map›Paper›PMID 33208922›Full record

ReviewNature reviews. Gastroenterology & hepatology2021

Dietary fibre in gastrointestinal health and disease.

Samantha K Gill, Megan Rossi, Balazs Bajka, Kevin Whelan

3 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Gastroenterology & hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 414 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
414citing papers in PubMed, 11 pooled it
44.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06395324 nacompletednot on this mapstarted 2024, after this paper: background citation

Fiber Effectively Educates & Directs the Microbiome Study

TypeinterventionalSponsorUniversity of California, DavisRan2024 to 2025Enrolled48ConditionsMicrobial ColonizationArmsHigh arabinose diet
NCT06515210 narecruitingnot on this mapstarted 2025, after this paper: background citation

Clinical Profiling of Anti-inflammatory Fibre Supplements in Patients With Ulcerative Colitis: Towards Personalized Complementary Strategies.

TypeinterventionalSponsorUniversity of AlbertaRan2025 to 2027Enrolled69ConditionsUlcerative ColitisArmsAcacia Gum, Microcrystalline Cellulose, Placebo
NCT06714552 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of the Replacement of Glycaemic Carbohydrates With Galacto-Oligosaccharide (GOS) Supplementation on Postprandial Glycaemic Response in Healthy Adults

TypeinterventionalSponsorUniversity of AberdeenRan2025 to 2026Enrolled50ConditionsPostprandial Hyperglycemia, HyperinsulinemiaArmsGalacto-Oligosaccharide, Glucose
3 · Its place in the literature

Who cites it

414 citing papers in PubMed, 11 syntheses or guidelines pooled it, 893 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Guideline
  6. Pooled it
  7. Pooled it
  8. Guideline
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Review
  19. Article
  20. Review

354 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Samantha K GillKing's College London, Department of Nutritional Sciences, London, UK.
Megan RossiKing's College London, Department of Nutritional Sciences, London, UK.
Balazs BajkaKing's College London, Department of Nutritional Sciences, London, UK.
Kevin WhelanKing's College London, Department of Nutritional Sciences, London, UK. kevin.whelan@kcl.ac.uk.
King's College London · GB

Funding

Medical Research Council MR/N029097/1
6 · The paper itself

Abstract

Epidemiological studies have consistently demonstrated the benefits of dietary fibre on gastrointestinal health through consumption of unrefined whole foods, such as wholegrains, legumes, vegetables and fruits. Mechanistic studies and clinical trials on isolated and extracted fibres have demonstrated promising regulatory effects on the gut (for example, digestion and absorption, transit time, stool formation) and microbial effects (changes in gut microbiota composition and fermentation metabolites) that have important implications for gastrointestinal disorders. In this Review, we detail the major physicochemical properties and functional characteristics of dietary fibres, the importance of dietary fibres and current evidence for their use in the management of gastrointestinal disorders. It is now well-established that the physicochemical properties of different dietary fibres (such as solubility, viscosity and fermentability) vary greatly depending on their origin and processing and are important determinants of their functional characteristics and clinical utility. Although progress in understanding these relationships has uncovered potential therapeutic opportunities for dietary fibres, many clinical questions remain unanswered such as clarity on the optimal dose, type and source of fibre required in both the management of clinical symptoms and the prevention of gastrointestinal disorders. The use of novel fibres and/or the co-administration of fibres is an additional therapeutic approach yet to be extensively investigated.

Indexed as

Gastrointestinal MicrobiomeGastrointestinal TransitBiological AvailabilityConstipationDiarrheaDietary FiberDiverticular DiseasesFermentationHumansInflammatory Bowel DiseasesIntestinal MucosaIrritable Bowel SyndromeMicronutrientsPrebioticsSolubilityViscosityDietary FiberMicronutrientsPrebiotics

Identifiers

PMID33208922
OpenAlexW3035622135

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.