ArticleScientific reports2020
Transcranial direct current stimulation (tDCS) over the auditory cortex modulates GABA and glutamate: a 7 T MR-spectroscopy study.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07196423 (Glutamate Changes as a New Neurocognitive Marker in Psychosis), which is not on this map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Glutamate Changes as a New Neurocognitive Marker in Psychosis
Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- Contribution of Glutamatergic and GABAergic Mechanisms to the Plasticity-Modulating Effects of Dopamine in the Human Motor Cortex.Human brain mapping · 2025Trial
- tDCS modulates speech perception and production in second language learners.Scientific reports · 2022Trial
- Neuroimaging-Guided Insights into the Molecular and Network Mechanisms of Chronic Pain and Neuromodulation.International journal of molecular sciences · 2026Review
- Learning from missteps: Potential of transcranial electrical stimulation in neuropsychological rehabilitation.Journal of neuropsychology · 2025Review
- Article
- Distinct neurochemical predictors for different phases of decision-making learning.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Understanding and targeting repetitive behaviors and restricted interests in autism spectrum disorder via high-definition transcranial direct current stimulation: a study-protocol.BMC psychiatry · 2025Article
- Recurrent inhibition refines mental templates to optimize perceptual decisions.Science advances · 2024Article
- Consecutive Dual-Session Transcranial Direct Current Stimulation in Chronic Subjective Severe to Catastrophic Tinnitus with Normal Hearing.Journal of personalized medicine · 2024Article
- Neurochemical Predictors of Generalized Learning Induced by Brain Stimulation and Training.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Cerebellar non-invasive stimulation of social and emotional mentalizing: A meta-analysis.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- A study of long-term GABA and high-energy phosphate alterations in the primary motor cortex using anodal tDCS andFrontiers in human neuroscience · 2024Article
- Partially dissociative role of the left inferior frontal gyrus and left dorsolateral prefrontal cortex in reasoning.PloS one · 2024Article
- Dopamine Alters the Effect of Brain Stimulation on Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Multinuclear Magnetic Resonance Spectroscopy at Ultra-High-Field: Assessing Human Cerebral Metabolism in Healthy and Diseased States.Metabolites · 2023Review
- Microstructural and neurochemical plasticity mechanisms interact to enhance human perceptual decision-making.PLoS biology · 2023Article
- Depressive patient-derived GABA interneurons reveal abnormal neural activity associated with HTR2C.EMBO molecular medicine · 2023Article
- Transcranial burst electrical stimulation contributes to neuromodulatory effects in the rat motor cortex.Frontiers in neuroscience · 2023Article
- Impact of twice-a-day transcranial direct current stimulation intervention on cognitive function and motor cortex plasticity in patients with Alzheimer's disease.General psychiatry · 2023Article
- Transcranial electrical stimulation: How can a simple conductor orchestrate complex brain activity?PLoS biology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcranial direct current stimulation (tDCS) is one of the most prominent non-invasive electrical brain stimulation method to alter neuronal activity as well as behavioral processes in cognitive and perceptual domains. However, the exact mode of action of tDCS-related cortical alterations is still unclear as the results of tDCS studies often do not comply with the somatic doctrine assuming that anodal tDCS enhances while cathodal tDCS decreases neuronal excitability. Changes in the regional cortical neurotransmitter balance within the stimulated cortex, measured by excitatory and inhibitory neurotransmitter levels, have the potential to provide direct neurochemical underpinnings of tDCS effects. Here we assessed tDCS-induced modulations of the neurotransmitter concentrations in the human auditory cortex (AC) by using magnetic resonance spectroscopy (MRS) at ultra-high-field (7 T). We quantified inhibitory gamma-amino butyric (GABA) concentration and excitatory glutamate (Glu) and compared changes in the relative concentration of GABA to Glu before and after tDCS application. We found that both, anodal and cathodal tDCS significantly increased the relative concentration of GABA to Glu with individual temporal specificity. Our results offer novel insights for a potential neurochemical mechanism that underlies tDCS-induced alterations of AC processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.