Evidence map›Paper›PMID 33208866›Full record

ArticleScientific reports2020

Multicellular contractility contributes to the emergence of mesothelioma nodules.

Julia Tarnoki-Zach, Paul Stockhammer, Dona Greta Isai, Elod Mehes, Balint Szeder, Ildiko Kovacs, Edina Bugyik, Sandor Paku, Walter Berger, Sufi Mary Thomas and 4 more

Open access · goldAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 5 countries.

Julia Tarnoki-ZachDepartment of Biological Physics, Eotvos University, Budapest, Hungary.
Paul StockhammerDepartment of Thoracic Surgery, Ruhrlandklinik, University Duisburg-Essen, Essen, Germany.
Dona Greta IsaiDepartment of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS, USA.
Elod MehesDepartment of Biological Physics, Eotvos University, Budapest, Hungary.
Balint SzederInstitute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary.
Ildiko KovacsNational Koranyi Institute of Pulmonology, Budapest, Hungary.
Edina BugyikFirst Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Sandor PakuFirst Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Walter BergerDepartment of Medicine, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Sufi Mary ThomasDepartment of Otolaryngology, University of Kansas Medical Center, Kansas City, KS, USA.
Zoltan NeufeldSchool of Mathematics and Physics, University of Queensland, Brisbane, Australia.
Balazs DomeDivision of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Balazs HegedusDepartment of Thoracic Surgery, Ruhrlandklinik, University Duisburg-Essen, Essen, Germany.
Andras CzirokDepartment of Biological Physics, Eotvos University, Budapest, Hungary. aczirok@gmail.com.
Semmelweis University · HUUniversity of Kansas Medical Center · USEötvös Loránd University · HUComprehensive Cancer Center Vienna · ATInstitute of Molecular Life Sciences · HUMedical University of Vienna · ATOrszágos Korányi Tbc és Pulmonológiai Intézet · HURuhrlandklinik · DEUniversity of Queensland · AU

Funding

Morphogenetic Tissue Movements in Early EmbryosR01GM102801 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI CZIROK, ANDRAS · 2014 to 2017
$1.1M
Austrian Science Fund FWF I 2872NIGMS NIH HHS R01 GM102801
6 · The paper itself

Abstract

Malignant pleural mesothelioma (MPM) has an overall poor prognosis and unsatisfactory treatment options. MPM nodules, protruding into the pleural cavity may have growth and spreading dynamics distinct that of other solid tumors. We demonstrate that multicellular aggregates can develop spontaneously in the majority of tested MPM cell lines when cultured at high cell density. Surprisingly, the nodule-like aggregates do not arise by excessive local cell proliferation, but by myosin II-driven cell contractility. Prominent actin cables, spanning several cells, are abundant both in cultured aggregates and in MPM surgical specimens. We propose a computational model for in vitro MPM nodule development. Such a self-tensioned Maxwell fluid exhibits a pattern-forming instability that was studied by analytical tools and computer simulations. Altogether, our findings may underline a rational for targeting the actomyosin system in MPM.

Indexed as

ActinsAmidesAnimalsCell CountCell Line, TumorHeterocyclic Compounds, 4 or More RingsHumansMaleMesothelioma, MalignantMice, SCIDMyosinsPyridinesStochastic ProcessesTime-Lapse ImagingXenograft Model Antitumor AssaysActinsAmidesblebbistatinHeterocyclic Compounds, 4 or More RingsMyosinsPyridinesY 27632

Identifiers

PMID33208866
PMCPMC7675981
OpenAlexW3099768367

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.