ArticleNature communications2020
Genome-enabled discovery of anthraquinone biosynthesis in Senna tora.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 123 citations in OpenAlex.
- Multi-omics integrated analysis reveals the key metabolic regulation mechanisms of petal color in Phalaenopsis aphrodite Rchb.f.Plant cell reports · 2026Article
- Multi-Omics Insights Into Anthraquinone Biosynthesis in Rheum tanguticum.Plant biotechnology journal · 2026Article
- Population and pangenome analyses uncover the evolutionary dynamics of the peroxidase gene family in barley.BMC genomics · 2026Article
- The ubiquitin receptor StDA1 negatively regulates aurantio-obtusin biosynthesis by mediating the degradation of the StHDR1 protein in Senna tora seeds.Communications biology · 2026Article
- From assemblies to ancestry: Genomic advances illuminates legume evolution.Genetics and molecular biology · 2026Article
- Environmental control of anthraquinone-flavonoid accumulation in wild plant species: biosynthetic pathways, ecological drivers, and adaptive significance.Frontiers in plant science · 2026Review
- Article
- Functional characterization of two distinct classes of NADPH-cytochrome P450 reductases in Senna alexandrina Mill.Molecular biology reports · 2025Article
- Application and Progress of Genomics in Deciphering the Genetic Regulation Mechanisms of Plant Secondary Metabolites.Plants (Basel, Switzerland) · 2025Review
- Identification and characterization of compounds that improve plant photosynthesis and growth under light stress conditions.Communications biology · 2025Article
- Chromosome-level genome assembly and improved annotation of onion genome (Allium cepa L.).Scientific data · 2025Article
- Tocotrienols in Eleven Species ofMolecules (Basel, Switzerland) · 2025Article
- Microbial engineering for monocyclic aromatic compounds production.FEMS microbiology reviews · 2025Review
- Genome-wide analysis of MYB transcription factors in fourFrontiers in plant science · 2025Article
- De novo sequencing allows genome-wide identification of genes involved in galactomannan synthesis in locust bean (Ceratonia siliqua).DNA research : an international journal for rapid publication of reports on genes and genomes · 2024Article
- Transcriptomic Analysis of the Combined Effects of Methyl Jasmonate and Wounding on Flavonoid and Anthraquinone Biosynthesis inPlants (Basel, Switzerland) · 2024Article
- Loss of Lateral suppressor gene is associated with evolution of root nodule symbiosis in Leguminosae.Genome biology · 2024Article
- The genomes of seven economic Caesalpinioideae trees provide insights into polyploidization history and secondary metabolite biosynthesis.Plant communications · 2024Article
- Comparative transcriptome analysis and HPLC reveal candidate genes associated with synthesis of bioactive constituents inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- A chromosome-level genome reveals genome evolution and molecular basis of anthraquinone biosynthesis in Rheum palmatum.BMC plant biology · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
24 authors at 8 institutions in 3 countries.
Funding
Abstract
Senna tora is a widely used medicinal plant. Its health benefits have been attributed to the large quantity of anthraquinones, but how they are made in plants remains a mystery. To identify the genes responsible for plant anthraquinone biosynthesis, we reveal the genome sequence of S. tora at the chromosome level with 526 Mb (96%) assembled into 13 chromosomes. Comparison among related plant species shows that a chalcone synthase-like (CHS-L) gene family has lineage-specifically and rapidly expanded in S. tora. Combining genomics, transcriptomics, metabolomics, and biochemistry, we identify a CHS-L gene contributing to the biosynthesis of anthraquinones. The S. tora reference genome will accelerate the discovery of biologically active anthraquinone biosynthesis pathways in medicinal plants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.