ArticleNature communications2020
DNA synthesis for true random number generation.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- ZAT-DNA enables DNA data storage with molecular-layer non-replicability.Nature communications · 2026Article
- Flexible and Physically Unclonable Function Anti-Counterfeiting Labels via Multi-Level Dynamic Structural Color Encryption.Materials (Basel, Switzerland) · 2026Article
- Exploring the intersection of natural sciences and information technology via entropy and randomness.Nature communications · 2025Review
- Single-step discovery of high-affinity RNA ligands by UltraSelex.Nature chemical biology · 2025Article
- A Programmed DNA Dynamic Assembly-Guided Molecular Amplifier for Authentic Information Decryption.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Functional RNA mining using random high-throughput screening.Nucleic acids research · 2025Article
- A Deniable Encryption Method for Modulation-Based DNA Storage.Interdisciplinary sciences, computational life sciences · 2024Article
- DNA-Based Chemical Unclonable Functions for Cryptographic Anticounterfeit Tagging of Pharmaceuticals.ACS nano · 2024Article
- Chemical unclonable functions based on operable random DNA pools.Nature communications · 2024Article
- Multimodal dynamic and unclonable anti-counterfeiting using robust diamond microparticles on heterogeneous substrate.Nature communications · 2023Article
- Synthetic DNA applications in information technology.Nature communications · 2022Review
- A flexible and stretchable bionic true random number generator.Nano research · 2022Article
- Position Matters: Fluorescent Positional Isomers for Reliable Multichannel Encryption Devices.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Storing and Reading Information in Mixtures of Fluorescent Molecules.ACS central science · 2021Article
- Uncertainties in synthetic DNA-based data storage.Nucleic acids research · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The volume of securely encrypted data transmission required by today's network complexity of people, transactions and interactions increases continuously. To guarantee security of encryption and decryption schemes for exchanging sensitive information, large volumes of true random numbers are required. Here we present a method to exploit the stochastic nature of chemistry by synthesizing DNA strands composed of random nucleotides. We compare three commercial random DNA syntheses giving a measure for robustness and synthesis distribution of nucleotides and show that using DNA for random number generation, we can obtain 7 million GB of randomness from one synthesis run, which can be read out using state-of-the-art sequencing technologies at rates of ca. 300 kB/s. Using the von Neumann algorithm for data compression, we remove bias introduced from human or technological sources and assess randomness using NIST's statistical test suite.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.