ArticleNature communications2020
Fibronectin-based nanomechanical biosensors to map 3D surface strains in live cells and tissue.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Physics-informed displacement control for variable pattern printing with V-shaped PDMS stamps in roll-to-roll microcontact printing.Communications engineering · 2025Article
- Enhancing Skeletal Muscle Fiber Type Transition Through Substrate Coating Alteration in Myoblast Cell Culture.International journal of molecular sciences · 2025Article
- 3D bioprinting of collagen-based high-resolution internally perfusable scaffolds for engineering fully biologic tissue systems.Science advances · 2025Article
- Hypersensitive meta-crack strain sensor for real-time biomedical monitoring.Science advances · 2024Article
- Ultrasensitive detection of vital biomolecules based on a multi-purpose BioMEMS for Point of care testing: digoxin measurement as a case study.Scientific reports · 2024Article
- Tissue damage force estimation in porcine small intestine from its elasticity.International journal of computer assisted radiology and surgery · 2023Article
- Novel Temperature-Sensitive Hydrogel Promotes Wound Healing Through YAP and MEK-Mediated Mechanosensitivity.Advanced healthcare materials · 2022Article
- A soft and ultrasensitive force sensing diaphragm for probing cardiac organoids instantaneously and wirelessly.Nature communications · 2022Article
- A novel pathway for multiscale high-resolution time-resolved residual stress evaluation of laser-welded Eurofer97.Science advances · 2022Article
- Endothelial superoxide dismutase 2 is decreased in sickle cell disease and regulates fibronectin processing.Function (Oxford, England) · 2022Article
- Revisiting tissue tensegrity: Biomaterial-based approaches to measure forces across length scales.APL bioengineering · 2021Review
- Theranostic biomaterials for tissue engineering.Current opinion in biomedical engineering · 2021Article
- Vascularisation of pluripotent stem cell-derived myocardium: biomechanical insights for physiological relevance in cardiac tissue engineering.Pflugers Archiv : European journal of physiology · 2021Review
- Fibronectin-based nanomechanical biosensors to map 3D surface strains in live cells and tissue.Nature communications · 2020Article
- Personalized Medicine for Antibiotics: The Role of Nanobiosensors in Therapeutic Drug Monitoring.Journal of personalized medicine · 2020Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Mechanical forces are integral to cellular migration, differentiation and tissue morphogenesis; however, it has proved challenging to directly measure strain at high spatial resolution with minimal perturbation in living sytems. Here, we fabricate, calibrate, and test a fibronectin (FN)-based nanomechanical biosensor (NMBS) that can be applied to the surface of cells and tissues to measure the magnitude, direction, and strain dynamics from subcellular to tissue length-scales. The NMBS is a fluorescently-labeled, ultra-thin FN lattice-mesh with spatial resolution tailored by adjusting the width and spacing of the lattice from 2-100 µm. Time-lapse 3D confocal imaging of the NMBS demonstrates 2D and 3D surface strain tracking during mechanical deformation of known materials and is validated with finite element modeling. Analysis of the NMBS applied to single cells, cell monolayers, and Drosophila ovarioles highlights the NMBS's ability to dynamically track microscopic tensile and compressive strains across diverse biological systems where forces guide structure and function.
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