ArticleRegional anesthesia and pain medicine2021
Perioperative cannabis use: a longitudinal study of associated clinical characteristics and surgical outcomes.
Article in Regional anesthesia and pain medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Association between history of cannabis use and outcomes after total hip or knee arthroplasty: a systematic review and meta-analysis.Frontiers in public health · 2024Pooled it
- High-Risk Substance and Polysubstance Use Among Elective Surgery Patients: Prevalence and Risk Factors.Journal of the American College of Surgeons · 2026Article
- Effect of Comorbidities on Short-Term Postoperative Complications Following total Shoulder Arthroplasty: A TriNetX Study.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026Article
- Association of Perioperative Cannabis Use With Postoperative Opioid Consumption in Ankle Fracture Patients.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026Article
- Preoperative Cannabis Use and Postoperative Delirium in Older Adults Undergoing Major Noncardiac Surgery.Anesthesiology open · 2026Article
- Alcohol and Substance Use After Bariatric Surgery: Nutritional Risks and Clinical Implications in Long-Term Postoperative Care.Nutrients · 2026Review
- Cannabis Use and Outcomes in Breast Surgery.Plastic and reconstructive surgery. Global open · 2026Article
- Association of patient-reported substance use and postoperative pain.Regional anesthesia and pain medicine · 2026Article
- Cannabis use and acute postoperative pain outcomes in older adults: a propensity matched retrospective cohort study.Regional anesthesia and pain medicine · 2025Article
- Impact of Preexisting Substance Use Disorders on Prolonged Opioid Use and Postoperative Complications After Burns.Journal of burn care & research : official publication of the American Burn Association · 2025Article
- Prevalence of THC-Positive Urine Drug Screens in Patients Receiving Chronic Opioid Therapy: A Retrospective Review.Psychopharmacology bulletin · 2025Article
- Urine tests for THC in patients undergoing elective inpatient surgery: a nationwide longitudinal electronic health record study in US veterans.British journal of anaesthesia · 2025Article
- Do Medical and Recreational Marijuana State Laws Impact Trends in Postoperative Opioid Prescriptions Among Patients Who Have Undergone TJA?Clinical orthopaedics and related research · 2025Article
- Considerations for Anesthesia in Older Adults with Cannabis Use.Drugs & aging · 2024Review
- Marijuana and Its Implications in Breast Reduction Surgery Outcomes and Quality of Life: A Matched Analysis.Plastic and reconstructive surgery. Global open · 2024Article
- Perioperative Cannabis Use in Bariatric Patients: A Review of Outcomes and Proposed Clinical Pathway for Management.Obesity surgery · 2024Review
- Cannabis smoking and abdominal wall reconstruction outcomes: a propensity score-matched analysis.Hernia : the journal of hernias and abdominal wall surgery · 2024Article
- Herbal Cannabis and Depression: A Review of Findings Published over the Last Three Years.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Preoperative Cannabis Use Did Not Increase Opioid Utilization After Primary Total Knee Arthroplasty in a Propensity Score-Matched Model.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2024Article
- Potential perioperative cardiovascular outcomes in cannabis/cannabinoid users. A call for caution.Frontiers in cardiovascular medicine · 2024Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDespite increases in cannabis use generally and for pain management, data regarding cannabis use in patients undergoing surgery are lacking. This study examined the prevalence of cannabis use among patients undergoing elective surgery and explored differences in clinical characteristics and surgical outcomes between cannabis users and non-cannabis users.
methodsThis prospective study included 1335 adults undergoing elective surgery. Participants completed self-report questionnaires preoperative and at 3-month and 6-month postsurgery to assess clinical characteristics and surgical outcomes.
resultsOverall, 5.9% (n=79) of patients reported cannabis use (53.2% medical, 19.0% recreational and 25.3% medical and recreational). On the day of surgery, cannabis users reported worse pain, more centralized pain symptoms, greater functional impairment, higher fatigue, greater sleep disturbances and more symptoms of anxiety and depression versus non-cannabis users (all p<0.01). Additionally, a larger proportion of cannabis users reported opioid (27.9%) and benzodiazepine use (19.0%) compared with non-cannabis users (17.5% and 9.2%, respectively). At 3 and 6 months, cannabis users continued to report worse clinical symptoms; however, both groups showed improvement across most domains (p≤0.05). At 6 months, the groups did not differ on surgical outcomes, including surgical site pain (p=0.93) or treatment efficacy (p=0.88).
conclusionsCannabis use is relatively low in this surgical population, yet cannabis users have higher clinical pain, poorer scores on quality of life indicators, and higher opioid use before and after surgery. Cannabis users reported similar surgical outcomes, suggesting that cannabis use did not impede recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.