Evidence map›Paper›PMID 33208500›Full record

ArticleScience translational medicine2020

Selene Lomoio, Rachel Willen, WonHee Kim, Kevin Z Ho, Edward K Robinson, Dmitry Prokopenko, Matthew E Kennedy, Rudolph E Tanzi, Giuseppina Tesco

Open access · greenAbstract read
In one paragraph

Article in Science translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Article
  5. Article
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  7. Review
  8. Article
  9. Article
  10. Towards a Unitary Hypothesis of Alzheimer's Disease Pathogenesis.Journal of Alzheimer's disease : JAD · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Selene LomoioDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA.ORCID 0000-0002-5151-295X
Rachel WillenDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA.
WonHee KimDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA.ORCID 0000-0001-5530-7606
Kevin Z HoDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA.
Edward K RobinsonDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA.
Dmitry ProkopenkoGenetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.ORCID 0000-0002-1844-5652
Matthew E KennedyDepartment of Neuroscience, Merck & Co. Inc., Boston, MA 02115, USA.ORCID 0000-0002-4842-4529
Rudolph E TanziGenetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.ORCID 0000-0002-7032-1454
Giuseppina TescoDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA. giuseppina.tesco@tufts.edu.ORCID 0000-0002-3336-7488
Tufts University · USHarvard University · USMerck & Co., Inc., Rahway, NJ, USA (United States) · US

Funding

Tufts Post-Baccalaureate Research Education ProgramR25GM066567 · NIGMS · TUFTS UNIVERSITY BOSTON · PI RIOS, MARIBEL · 2002 to 2024
$5.7M
BACE1 trafficking and degradation in Alzheimer’s diseaseRF1AG057148 · NIA · TUFTS UNIVERSITY BOSTON · PI TESCO, GIUSEPPINA · 2017 to 2017
$3.1M
Building Diversity in Biomedical SciencesR25HL007785 · NHLBI · TUFTS UNIVERSITY BOSTON · PI MAGUIRE, JAMIE LYNN · 2008 to 2024
$2.0M
NHLBI NIH HHS R25 HL007785NIA NIH HHS RF1 AG057148NIGMS NIH HHS R25 GM066567
6 · The paper itself

Abstract

Axonal dystrophy, indicative of perturbed axonal transport, occurs early during Alzheimer's disease (AD) pathogenesis. Little is known about the mechanisms underlying this initial sign of the pathology. This study proves that Golgi-localized γ-ear-containing ARF binding protein 3 (GGA3) loss of function, due to

Indexed as

Alzheimer DiseaseAdaptor Proteins, Vesicular TransportAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAnimalsAspartic Acid EndopeptidasesAxonsMiceAdaptor Proteins, Vesicular TransportAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesBace1 protein, mouseGGA adaptor proteins

Identifiers

PMID33208500
PMCPMC8612295
OpenAlexW3100220025

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.