Evidence map›Paper›PMID 33208486›Full record

SynthesisEuropean respiratory review : an official journal of the European Respiratory Society2020

Design of pulmonary rehabilitation programmes during acute exacerbations of COPD: a systematic review and network meta-analysis.

Ana Machado, Pedro Matos Silva, Vera Afreixo, Cátia Caneiras, Chris Burtin, Alda Marques

Erratum issuedAbstract readSystematic ReviewNetwork Meta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European respiratory review : an official journal of the European Respiratory Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Effectiveness of Nonpharmacological Interventions in the Field of Ventilation: An Umbrella Review.International journal of environmental research and public health · 2023
    Pooled it
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  7. Trial
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  10. Article
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  14. Content, uptake and adherence of exercise interventions after an acute exacerbation of COPD: a scoping review.European respiratory review : an official journal of the European Respiratory Society · 2025
    Article
  15. Article
  16. PD-1Respiratory research · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Giving Voice to People - Experiences During Mild to Moderate Acute Exacerbations of COPD.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Ana MachadoRespiratory Research and Rehabilitation Laboratory (Lab 3R), School of Health Sciences (ESSUA), University of Aveiro, Aveiro, Portugal.
Pedro Matos SilvaUnidade Local de Saúde de Matosinhos, Matosinhos, Portugal.
Vera AfreixoInstitute for Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal.
Cátia CaneirasHealthcare Dept, Nippon Gases Portugal, Vila Franca de Xira, Portugal.ORCID https://orcid.org/0000-0002-3735-8554
Chris BurtinREVAL - Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, Diepenbeek, Belgium.
Alda MarquesRespiratory Research and Rehabilitation Laboratory (Lab 3R), School of Health Sciences (ESSUA), University of Aveiro, Aveiro, Portugal amarques@ua.pt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This systematic review aimed to systematise the different designs used to deliver pulmonary rehabilitation during acute exacerbations of COPD (AECOPD) and explore which ones are the most effective. PubMed, Scopus, Web of Science, EBSCO and Cochrane were searched. Randomised controlled trials comparing pulmonary rehabilitation or at least one of its components with usual care or comparing different components of pulmonary rehabilitation were included. Network meta-analysis was conducted in MetaXL 5.3 using a generalised pairwise modelling framework. Pooled effects compared each treatment to usual care. 42 studies were included. Most studies were conducted in an inpatient setting (57%) and started the intervention 24-48 h after hospital admission (24%). Exercise training (71%), education and psychosocial support (57%) and breathing techniques (55%) were the most used components. Studies combining exercise with breathing techniques presented the larger effects on exercise capacity (weighted mean difference (WMD) -41.06, 95% CI -131.70-49.58) and health-related quality of life (WMD 16.07, 95% CI 10.29-21.84), and breathing techniques presented the larger effects on dyspnoea (WMD 1.90, 95% CI 0.53-3.27) and length of hospitalisation (effect size =0.15, 95% CI -0.28-0.57). A few minor adverse events were found.Pulmonary rehabilitation is a safe intervention during AECOPD. Exercise, breathing techniques, and education and psychosocial support seem to be the core components for implementing pulmonary rehabilitation during AECOPD. Studies may now focus on comparisons of optimal timings to start the intervention, total duration of the intervention, duration and frequency of sessions, and intensity for exercise prescription.

Indexed as

Pulmonary Disease, Chronic ObstructiveQuality of LifeDyspneaExercise ToleranceHumans

Identifiers

PMID33208486
PMCPMC9488534

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.