ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Content.
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Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 33 citations in OpenAlex.
- Balancing cellular copper levels via the post-translational regulation of copper transport.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Review
- COG5 deficiency disrupts cellular copper homeostasis and underlies the impaired mitochondrial OXPHOS function.PLoS genetics · 2026Article
- Context-dependent ATP7 Interactions with Parkinson's Disease-associated Genes Modulate Copper Homeostasis Phenotypes.bioRxiv : the preprint server for biology · 2026Article
- Distinct signaling mechanisms and proteome phenotypes are elicited by compartment-specific genetic defects of copper homeostasis.bioRxiv : the preprint server for biology · 2026Article
- Roles of cuproptosis in central nervous system tumors: from molecular mechanisms to therapeutic prospects.Frontiers in cell and developmental biology · 2026Review
- ATPase copper transporting beta contributes to cisplatin resistance as a regulatory factor of extracellular vesicles in head and neck squamous cell carcinoma.Cancer gene therapy · 2026Article
- Copper Homeostasis, Emerging Central Players in Cancer Immunotherapy.Journal of cellular and molecular medicine · 2025Review
- A primer on copper biology in the brain.Neurobiology of disease · 2025Review
- The molecular mechanism and therapeutic landscape of copper and cuproptosis in cancer.Signal transduction and targeted therapy · 2025Review
- Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration.Molecular biology of the cell · 2025Article
- Copper homeostasis and cuproptosis: implications for neurodegenerative diseases.Frontiers in aging neuroscience · 2025Review
- Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration.bioRxiv : the preprint server for biology · 2024Article
- Acute GARP depletion disrupts vesicle transport, leading to severe defects in sorting, secretion, and O-glycosylation.bioRxiv : the preprint server for biology · 2024Article
- New BDNF and NT-3 Cyclic Mimetics Concur with Copper to Activate Trophic Signaling Pathways as Potential Molecular Entities to Protect Old Brains from Neurodegeneration.Biomolecules · 2024Article
- The physiological and pathophysiological roles of copper in the nervous system.The European journal of neuroscience · 2024Review
- Zinc, Copper, and Calcium: A Triangle in the Synapse for the Pathogenesis of Vascular-Type Senile Dementia.Biomolecules · 2024Review
- Copper Metabolism and Cuproptosis: Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases.Current medical science · 2024Review
- The organization and function of the Golgi apparatus in dendrite development and neurological disorders.Genes & diseases · 2023Review
- Excessive copper impairs intrahepatocyte trafficking and secretion of selenoprotein P.Nature communications · 2023Article
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Authors and funding
22 authors at 8 institutions in 4 countries.
Cortnie HartwigDepartments of Cell Biology, Emory University, Atlanta, Georgia 30322.ORCID 0000-0002-6612-0780
Gretchen Macías MéndezNeuroscience Department, Universidad Central del Caribe, Bayamon, Puerto Rico 00956.
Shatabdi BhattacharjeeNeuroscience Institute, Center for Behavioral Neuroscience, Georgia State University, Atlanta, Georgia 30302.
Alysia D Vrailas-MortimerSchool of Biological Sciences, IL State University, Normal, Illinois 617901.
Stephanie A ZlaticDepartments of Cell Biology, Emory University, Atlanta, Georgia 30322.ORCID 0000-0003-0758-9500
Amanda A H FreemanThe Center for the Study of Human Health, Emory University, Atlanta, Georgia 30322.ORCID 0000-0003-0084-7618
Avanti GokhaleDepartments of Cell Biology, Emory University, Atlanta, Georgia 30322.ORCID 0000-0001-7432-8541
Mafalda ConcilliTelethon Institute of Genetics and Medicine (TIGEM), Pozzuoli 80078, Italy.
Erica WernerDepartments of Cell Biology, Emory University, Atlanta, Georgia 30322.
Christie Sapp SavasDepartments of Cell Biology, Emory University, Atlanta, Georgia 30322.
Samantha Rudin-RushDepartments of Cell Biology, Emory University, Atlanta, Georgia 30322.
Laura PalmerDepartments of Cell Biology, Emory University, Atlanta, Georgia 30322.
Nicole ShearingDepartments of Cell Biology, Emory University, Atlanta, Georgia 30322.
Lindsey MargewichSchool of Biological Sciences, IL State University, Normal, Illinois 617901.
Jacob McArthySchool of Biological Sciences, IL State University, Normal, Illinois 617901.
Savanah TaylorSchool of Biological Sciences, IL State University, Normal, Illinois 617901.
Blaine RobertsDepartments of Biochemistry, Emory University, Atlanta, Georgia 30322.
Vladimir LupashinDepartment of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205.
Roman S PolishchukTelethon Institute of Genetics and Medicine (TIGEM), Pozzuoli 80078, Italy.
Daniel N CoxNeuroscience Institute, Center for Behavioral Neuroscience, Georgia State University, Atlanta, Georgia 30302.ORCID 0000-0001-9191-9212
Ramon A JorqueraNeuroscience Department, Universidad Central del Caribe, Bayamon, Puerto Rico 00956 ramon.jorquera@unab.cl vfaunde@emory.edu.
Victor FaundezDepartments of Cell Biology, Emory University, Atlanta, Georgia 30322 ramon.jorquera@unab.cl vfaunde@emory.edu.ORCID 0000-0002-2114-5271
Emory University · USIllinois State University · USGeorgia State University · USTelethon Institute Of Genetics And Medicine · ITCentral University of the Caribbean · PREmory Healthcare · USUniversidad Andrés Bello · CLUniversity of Arkansas for Medical Sciences · US
Funding
IRACDA Fellowships in Research and Science Training (FIRST)K12GM000680 · NIGMS · EMORY UNIVERSITY · PI BROWN, LOU ANN S, MCCARTY, NAEL A · 2000 to 2024
$41.2MAnatomical characterization of neuronal cell types of the mouse brainU01MH114829 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ASCOLI, GIORGIO A, DONG, HONG-WEI · 2017 to 2021
$13.9MResource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI KEVIN R COOK · 2014 to 2026
$13.5MCharacterization of mammalian COG complex-interacting intra-Golgi trafficking macR01GM083144 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI VLADIMIR V LUPASHIN · 2008 to 2026
$6.5MRegulation of synaptic vesicle mobilization,priming and recycling by complexinU54NS083924 · NINDS · UNIVERSIDAD CENTRAL DEL CARIBE · PI BYKHOVSKAIA, MARIA · 2013 to 2015
$4.3MCytoskeletal mechanisms of dendrite arbor shape developmentR01NS086082 · NINDS · GEORGIA STATE UNIVERSITY · PI ASCOLI, GIORGIO A, COX, DANIEL N · 2013 to 2023
$3.1MNeuronal Mechanisms of Copper Transport and ToxicityRF1AG060285 · NIA · EMORY UNIVERSITY · PI FAUNDEZ, VICTOR · 2018 to 2021
$2.4MSynaptic Modifications Induced by Starvation at Drosophila NMJR01NS108778 · NINDS · UNIVERSIDAD CENTRAL DEL CARIBE · PI JORQUERA, RAMON A · 2018 to 2020
$713kThe Role of p38K and protein homeostasis in Limb-Girdle Muscular DystrophiesR15AR070505 · NIAMS · ILLINOIS STATE UNIVERSITY · PI VRAILAS-MORTIMER, ALYSIA DANIELLE · 2016 to 2016
$435kNIAMS NIH HHS R15 AR070505NIA NIH HHS RF1 AG060285NIGMS NIH HHS K12 GM000680NIGMS NIH HHS R01 GM083144NIH HHS P40 OD018537NIMH NIH HHS U01 MH114829NINDS NIH HHS R01 NS086082NINDS NIH HHS R01 NS108778NINDS NIH HHS U54 NS083924
Abstract
Rare genetic diseases preponderantly affect the nervous system causing neurodegeneration to neurodevelopmental disorders. This is the case for both Menkes and Wilson disease, arising from mutations in ATP7A and ATP7B, respectively. The ATP7A and ATP7B proteins localize to the Golgi and regulate copper homeostasis. We demonstrate genetic and biochemical interactions between ATP7 paralogs with the conserved oligomeric Golgi (COG) complex, a Golgi apparatus vesicular tether. Disruption of
Indexed as
Organelle BiogenesisAdenosine TriphosphatasesAnimalsAnimals, Genetically ModifiedCell LineCopperCopper-Transporting ATPasesDrosophilaElectric StimulationExtracellular SpaceFemaleGolgi ApparatusHomeostasisHumansMaleRNA, Small InterferingAdenosine TriphosphatasesATP7 protein, DrosophilaCopperCopper-Transporting ATPasesRNA, Small InterferingATP7AcopperGolgiMenkesmitochondriaWilson
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