Evidence map›Paper›PMID 33208465›Full record

ArticleThe Journal of biological chemistry

DNA damage promotes ER stress resistance through elevation of unsaturated phosphatidylcholine in Caenorhabditis elegans.

Jianhui Deng, Xue Bai, Haiqing Tang, Shanshan Pang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. mSystems · 2026
    Article
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jianhui DengSchool of Life Sciences, Chongqing University, Chongqing, China.
Xue BaiSchool of Life Sciences, Chongqing University, Chongqing, China.
Haiqing TangSchool of Life Sciences, Chongqing University, Chongqing, China. Electronic address: hqtang@cqu.edu.cn.
Shanshan PangSchool of Life Sciences, Chongqing University, Chongqing, China. Electronic address: sspang@cqu.edu.cn.
Chongqing University · CN

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

DNA damage triggers the cellular adaptive response to arrest proliferation and repair DNA damage; when damage is too severe to be repaired, apoptosis is initiated to prevent the spread of genomic insults. However, how cells endure DNA damage to maintain cell function remains largely unexplored. By using Caenorhabditis elegans as a model, we report that DNA damage elicits cell maintenance programs, including the unfolded protein response of the endoplasmic reticulum (UPR

Indexed as

DNA DamageEndoplasmic Reticulum StressAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCarrier ProteinsDNA-Binding ProteinsPhosphatidylcholinesProtein Serine-Threonine KinasesTranscription FactorsUnfolded Protein ResponseCaenorhabditis elegans ProteinsCarrier ProteinsDNA-Binding ProteinsIRE-1 protein, C elegansPhosphatidylcholinesProtein Serine-Threonine Kinasesskn-1 protein, C elegansTranscription FactorsXBP-1 protein, C elegansapoptotic genesC. elegansDNA damage responseER stress responsefatty acidphosphatidylcholineSKN-1

Identifiers

PMID33208465
PMCPMC7949029
OpenAlexW3102612541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.