Evidence map›Paper›PMID 33208451›Full record

ArticleJournal of virology2021

Impact of a Demyelination-Inducing Central Nervous System Virus on Expression of Demyelination Genes in Type 2 Lymphoid Cells.

Satoshi Hirose, Mihoko Kato, Kati Tormanen, Pedram Shafiei Jahani, Omid Akbari, Homayon Ghiasi

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Satoshi HiroseCenter for Neurobiology & Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Mihoko KatoDepartment of Biology, Pomona College, Claremont, California, USA.
Kati TormanenCenter for Neurobiology & Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Pedram Shafiei JahaniDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Omid AkbariDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Homayon GhiasiCenter for Neurobiology & Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA ghiasih@CSHS.org.ORCID 0000-0003-3291-1995
Cedars-Sinai Medical Center · USUniversity of Southern California · USPomona College · US

Funding

Role of Macrophages in control of Ocular HSVR01EY024649 · NEI · CEDARS-SINAI MEDICAL CENTER · PI HOMAYON GHIASI · 2015 to 2026
$4.1M
Induction of cells and pathways that promote respiratory tolerance in allergic asthmaR01HL144790 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AKBARI, OMID · 2019 to 2022
$2.6M
Role of type 2 Innate Lymphoid Cells (ILC2s) in optic neuritisR01EY029677 · NEI · CEDARS-SINAI MEDICAL CENTER · PI GHIASI, HOMAYON · 2019 to 2022
$1.8M
NEI NIH HHS R01 EY024649NEI NIH HHS R01 EY029677NHLBI NIH HHS R01 HL144790
6 · The paper itself

Abstract

We recently reported the role of type 2 innate lymphoid cells (ILC2s) in central nervous system (CNS) demyelination using a model of CNS demyelination involving recombinant herpes simplex virus 1 (HSV-1) that constitutively expresses mouse interleukin 2 (HSV-IL-2). In this investigation, we studied how ILC2s respond to HSV-IL-2 at the cellular level using cytokine and gene expression profiling. ILC2s infected with HSV-IL-2 expressed higher levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-5, IL-6, IL-13, IP-10, MIP-2, and RANTES, which include proinflammatory cytokines, than did those infected with parental control virus. In contrast, T

Indexed as

Demyelinating DiseasesLymphocytesAnimalsCells, CulturedCytokinesGene ExpressionHerpesvirus 1, HumanInterleukin-2MiceMice, Inbred C57BLRabbitsTranscriptomeCytokinesInterleukin-2central nervous system infectionschemokinescytokinesdemyelinationHSV-1HSV-IL-2IL-2ILC2sinfectionRNA-seq

Identifiers

PMID33208451
PMCPMC7851570
OpenAlexW3101437320

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.