Evidence map›Paper›PMID 33208446›Full record

ArticleJournal of virology2021

Epstein-Barr Virus-Encoded Latent Membrane Protein 1 and B-Cell Growth Transformation Induce Lipogenesis through Fatty Acid Synthase.

Michael Hulse, Sarah M Johnson, Sarah Boyle, Lisa Beatrice Caruso, Italo Tempera

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. SIRT2 deacylase modulators control B cell metabolic reprogramming in EBV infection and mitogenic activation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  17. Multiple sclerosis and infection: history, EBV, and the search for mechanism.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  18. CAMKIIδ Reinforces Lipid Metabolism and Promotes the Development of B Cell Lymphoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  19. Understanding Metabolic Pathway Rewiring by Oncogenic Gamma Herpesvirus.Journal of microbiology and biotechnology · 2024
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Michael Hulse *Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Sarah M Johnson *Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Sarah BoyleThe Wistar Institute, Philadelphia, Pennsylvania, USA.
Lisa Beatrice CarusoThe Wistar Institute, Philadelphia, Pennsylvania, USA.
Italo TemperaThe Wistar Institute, Philadelphia, Pennsylvania, USA itempera@wistar.org.ORCID 0000-0001-7893-2914
The Wistar Institute · USTemple University · US

Funding

Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9M
Regulation of Viral Chromatin Architecture During EBV LatencyR01AI130209 · NIAID · WISTAR INSTITUTE · PI Italo Tempera · 2018 to 2026
$3.8M
Advancing Cancer Research through Comprehensive Proteomics and Metabolomics AnalysesR50CA221838 · NCI · WISTAR INSTITUTE · PI Hsin-Yao Tang · 2017 to 2026
$2.1M
Purchase of a Q Exactive HF mass spectrometer system for metabolomicsS10OD023586 · OD · WISTAR INSTITUTE · PI SPEICHER, DAVID W. · 2017 to 2017
$600k
NCI NIH HHS P30 CA010815NCI NIH HHS R50 CA221838NIAID NIH HHS R01 AI130209NIH HHS S10 OD023586
6 · The paper itself

Abstract

Latent membrane protein 1 (LMP1) is the major transforming protein of Epstein-Barr virus (EBV) and is critical for EBV-induced B-cell transformation

Indexed as

B-LymphocytesCell Transformation, NeoplasticLipogenesisCell Line, TumorCellular ReprogrammingEpstein-Barr Virus InfectionsFatty Acid Synthase, Type IHerpesvirus 4, HumanHumansViral Matrix ProteinsEBV-associated membrane antigen, Epstein-Barr virusFASN protein, humanFatty Acid Synthase, Type IViral Matrix Proteinscell transformationEpstein-Barr virusFASNlipogenesisLMP1metabolismPARP1

Identifiers

PMID33208446
PMCPMC7851568
OpenAlexW3106185452

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.