ArticleScience advances2020
Revealing nanoscale mineralization pathways of hydroxyapatite using in situ liquid cell transmission electron microscopy.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- A novel treatment based on powder jet deposition technique for dentin hypersensitivity: a randomized controlled trial.BMC oral health · 2023Trial
- High-throughput synthesis of zinc-functionalized bio-ceramics propels the rational design of bone implants.Bioactive materials · 2026Article
- The genesis of citrated ultrathin hydroxyapatite nanorods.Science advances · 2026Article
- Biomimetic Enamel-like Crystals: A Versatile Platform for Unraveling the Basic Mechanisms of Demineralization and Remineralization.ACS applied materials & interfaces · 2025Article
- Design Principles Of Inorganic-Protein Hybrid Materials for Biomedicine.Exploration (Beijing, China) · 2025Review
- Bioinspired Nanoscale 3D Printing of Calcium Phosphates Using Bone Prenucleation Clusters.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Evidence for a possible quantum effect on the formation of lithium-doped amorphous calcium phosphate from solution.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Biomineralized PEEK cages containing osteoinductive CaP bioceramics promote spinal fusion in goats.Bioactive materials · 2025Article
- Electro-spun piezoelectric PLLA smart composites as a scaffold on bone fracture: A review.Regenerative therapy · 2025Review
- Bone Regeneration: Mini-Review and Appealing Perspectives.Bioengineering (Basel, Switzerland) · 2025Review
- The glycerol stabilized calcium phosphate cluster for rapid remineralization of tooth enamel by a water-triggered transformation.Nature communications · 2025Article
- Exploring Biomineralization Processes Using In Situ Liquid Transmission Electron Microscopy: A Review.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Dynamic Nuclear Polarization Enhanced Multiple-Quantum Spin Counting of Molecular Assemblies in Vitrified Solutions.The journal of physical chemistry letters · 2024Article
- Highly Stable Amorphous (Pyro)phosphate Aggregates: Pyrophosphate as a Carrier for Bioactive Ions and Drugs in Bone Repair Applications.ACS omega · 2024Article
- Development of Hydroxyapatite Coatings for Orthopaedic Implants from Colloidal Solutions: Part 1-Effect of Solution Concentration and Deposition Kinetics.Nanomaterials (Basel, Switzerland) · 2023Article
- Nucleation and Crystallization of Ferrous Phosphate Hydrate via an Amorphous Intermediate.Journal of the American Chemical Society · 2023Article
- Article
- Tissue-Engineered Nanomaterials Play Diverse Roles in Bone Injury Repair.Nanomaterials (Basel, Switzerland) · 2023Review
- Anionic Polysaccharide Cryogels: Interaction and In Vitro Behavior of Alginate-Gum Arabic Composites.Polymers · 2023Article
- Regulation of Hydroxyapatite Nucleation In Vitro through Ameloblastin-Amelogenin Interactions.ACS biomaterials science & engineering · 2023Article
Corrections and comments
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Authors and funding
15 authors.
Funding
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Abstract
To treat impairments in hard tissues or overcome pathological calcification in soft tissues, a detailed understanding of mineralization pathways of calcium phosphate materials is needed. Here, we report a detailed mechanistic study of hydroxyapatite (HA) mineralization pathways in an artificial saliva solution via in situ liquid cell transmission electron microscopy (TEM). It is found that the mineralization of HA starts by forming ion-rich and ion-poor solutions in the saliva solution, followed by coexistence of the classical and nonclassical nucleation processes. For the nonclassical path, amorphous calcium phosphate (ACP) functions as the substrate for HA nucleation on the ACP surface, while the classical path features direct HA nucleation from the solution. The growth of HA crystals on the surface of ACP is accompanied by the ACP dissolution process. The discoveries reported in this work are important to understand the physiological and pathological formation of HA minerals, as well as to engineer the biomineralization process for bone healing and hard tissue repairs.
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