Evidence map›Paper›PMID 33208365›Full record

ArticleScience advances2020

Network-based atrophy modeling in the common epilepsies: A worldwide ENIGMA study.

Sara Larivière, Raúl Rodríguez-Cruces, Jessica Royer, Maria Eugenia Caligiuri, Antonio Gambardella, Luis Concha, Simon S Keller, Fernando Cendes, Clarissa Yasuda, Leonardo Bonilha and 52 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 3 pooled it
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 3 syntheses or guidelines pooled it, 191 citations in OpenAlex.

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39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

62 authors at 20 institutions in 14 countries.

Sara LarivièreMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.ORCID 0000-0001-5701-1307
Raúl Rodríguez-CrucesMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Jessica RoyerMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Maria Eugenia CaligiuriNeuroscience Research Center, University Magna Græcia, Catanzaro, CZ, Italy.
Antonio GambardellaNeuroscience Research Center, University Magna Græcia, Catanzaro, CZ, Italy.
Luis ConchaInstitute of Neurobiology, Universidad Nacional Autónoma de México, Querétaro, México.
Simon S KellerInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Fernando CendesDepartment of Neurology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.
Clarissa YasudaDepartment of Neurology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.ORCID 0000-0001-9084-7173
Leonardo BonilhaDepartment of Neurology, Medical University of South Carolina, Charleston, SC, USA.
Ezequiel GleichgerrchtDepartment of Neurology, Medical University of South Carolina, Charleston, SC, USA.
Niels K FockeDepartment of Clinical Neurophysiology, University of Medicine Göttingen, Göttingen, Germany.
Martin DominInstitute of Diagnostic Radiology and Neuroradiology, Functional Imaging Unit, University Medicine Greifswald, Greifswald, Germany.
Felix von PodewillsDepartment of Neurology, University Medicine Greifswald, Greifswald, Germany.
Soenke LangnerInstitute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
Christian RummelSupport Center for Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Bern, Switzerland.
Roland WiestSupport Center for Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Bern, Switzerland.
Pascal MartinDepartment of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Raviteja KotikalapudiDepartment of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Terence J O'BrienDepartment of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.
Benjamin SinclairDepartment of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.
Lucy VivashDepartment of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.
Patricia M DesmondDepartments of Medicine and Radiology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
Saud AlhusainiDepartment of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.
Colin P DohertyDepartment of Neurology, St. James' Hospital, Dublin, Ireland.
Gianpiero L CavalleriDepartment of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.ORCID 0000-0002-9802-0506
Norman DelantyDepartment of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.
Reetta KälviäinenEpilepsy Center, Neuro Center, Kuopio University Hospital, European Reference Network for Rare and Complex Epilepsies EpiCARE, Kuopio, Finland.
Graeme D JacksonFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria 3010, Australia.
Magdalena KowalczykFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria 3010, Australia.
Mario MascalchiNeuroradiology Research Program, Meyer Children Hospital of Florence, University of Florence, Florence, Italy.
Mira SemmelrochFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria 3010, Australia.
Rhys H ThomasTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Hamid Soltanian-ZadehControl and Intelligent Processing Center of Excellence (CIPCE), School of Electrical and Computer Engineering, University of Tehran, Tehran, Iran.
Esmaeil Davoodi-BojdDepartment of Neurology, Henry Ford Health System, Detroit, MI, USA.
Junsong ZhangCognitive Science Department, Xiamen University, Xiamen, China.
Matteo LengeChild Neurology Unit and Laboratories, Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy.
Renzo GuerriniChild Neurology Unit and Laboratories, Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy.
Emanuele BartoliniUSL Centro Toscana, Neurology Unit, Nuovo Ospedale Santo Stefano, Prato, Italy.
Khalid HamandiCardiff University Brain Research Imaging Centre (CUBRIC), College of Biomedical Sciences, Cardiff University, Cardiff, UK.
Sonya FoleyWelsh Epilepsy Unit, Department of Neurology, University Hospital of Wales, Cardiff, UK.
Bernd WeberInstitute of Experimental Epileptology and Cognition Research, University Hospital Bonn, Bonn, Germany.
Chantal DepondtDepartment of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.ORCID 0000-0002-8452-5319
Julie AbsilDepartment of Radiology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
Sarah J A CarrDivision of Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Eugenio AbelaDivision of Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Mark P RichardsonDivision of Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Orrin DevinskyDepartment of Neurology, NYU Grossman School of Medicine, New York, NY, USA.
Mariasavina SeverinoIRCCS Istituto Giannina Gaslini, Genova, Italy.
Pasquale StrianoIRCCS Istituto Giannina Gaslini, Genova, Italy.
Domenico TortoraIRCCS Istituto Giannina Gaslini, Genova, Italy.
Sean N HattonDepartment of Neurosciences, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, USA.
Sjoerd B VosDepartment of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK.
John S DuncanDepartment of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK.
Christopher D WhelanDepartment of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, USC Keck School of Medicine, Los Angeles, CA, USA.ORCID 0000-0002-4720-8867
Sanjay M SisodiyaDepartment of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK.
Andrea BernasconiNeuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Angelo LabateNeuroscience Research Center, University Magna Græcia, Catanzaro, CZ, Italy.
Carrie R McDonaldDepartment of Psychiatry, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, USA.
Neda BernasconiNeuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Boris C BernhardtMultimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada. boris.bernhardt@mcgill.ca.ORCID 0000-0001-9256-6041
Montreal Neurological Institute and Hospital · CARoyal College of Surgeons in Ireland · IEThe Royal Melbourne Hospital · AUIstituto Giannina Gaslini · ITKing's College London · GBMagna Graecia University · ITMeyer Children's Hospital · ITThe University of Melbourne · AUUniversitätsmedizin Greifswald · DEUniversity College London · GBHenry Ford Health System · USHertie Institute for Clinical Brain Research · DEMedical University of South Carolina · USUniversidade Estadual de Campinas (UNICAMP) · BRUniversité Libre de Bruxelles · BEUniversity Hospital of Wales · GBUniversity of California San Diego · USInstitute of Neurobiology · BGKeck Hospital of USC · USNewcastle University · GB

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
National Neuropsychological Network (NNN)R01MH118514 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DANIEL L DRANE, David W. Loring · 2019 to 2026
$9.4M
Multimodal Imaging of Language in the Preoperative Evaluation of EpilepsyR01NS065838 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCDONALD, CARRIE R · 2010 to 2018
$4.4M
Lifespan Epilepsy Network Signatures (LENS): Leveraging ENIGMA-Epilepsy to Predict Cognitive Aging and Surgical OutcomesR01NS122827 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CARRIE R MCDONALD · 2021 to 2026
$3.8M
Predicting Epilepsy Surgery Outcomes Using Neural Network ArchitectureR01NS110347 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BONILHA, LEONARDO F, DRANE, DANIEL L · 2019 to 2023
$3.6M
ENIGMA-SD: Understanding Sex Differences in Global Mental Health through ENIGMAR01MH116147 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2021
$2.5M
ENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683k
Prediction of seizure lateralization and postoperative outcome through the use of deep learning applied to multi-site MRI/DTI data: An ENIGMA-Epilepsy studyR21NS107739 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BONILHA, LEONARDO F, MCDONALD, CARRIE R · 2019 to 2019
$444k
Medical Research Council MR/K013998/1Medical Research Council MR/K023152/1NIA NIH HHS R56 AG058854NIBIB NIH HHS P41 EB015922NIBIB NIH HHS U54 EB020403NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH118514NIMH NIH HHS U54 MH091657NINDS NIH HHS R01 NS065838NINDS NIH HHS R01 NS110347NINDS NIH HHS R01 NS122827NINDS NIH HHS R21 NS107739
6 · The paper itself

Abstract

Epilepsy is increasingly conceptualized as a network disorder. In this cross-sectional mega-analysis, we integrated neuroimaging and connectome analysis to identify network associations with atrophy patterns in 1021 adults with epilepsy compared to 1564 healthy controls from 19 international sites. In temporal lobe epilepsy, areas of atrophy colocalized with highly interconnected cortical hub regions, whereas idiopathic generalized epilepsy showed preferential subcortical hub involvement. These morphological abnormalities were anchored to the connectivity profiles of distinct disease epicenters, pointing to temporo-limbic cortices in temporal lobe epilepsy and fronto-central cortices in idiopathic generalized epilepsy. Negative effects of age on atrophy further revealed a strong influence of connectome architecture in temporal lobe, but not idiopathic generalized, epilepsy. Our findings were reproduced across individual sites and single patients and were robust across different analytical methods. Through worldwide collaboration in ENIGMA-Epilepsy, we provided deeper insights into the macroscale features that shape the pathophysiology of common epilepsies.

Identifiers

PMID33208365
PMCPMC7673818
OpenAlexW3105086774

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.