ArticleBMJ open2020
Occurrence, mortality and cost of brain disorders in Denmark: a population-based cohort study.
Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Epidemiology and Economic Burden of Sleep Disorders in Europe.European journal of neurology · 2026Pooled it
- The Danish Region Midt Schizophrenia Cohort - Representative, long-term follow-up of first-episode schizophrenia spectrum disorder.Acta neuropsychiatrica · 2026Article
- Long-Term Exposure to Air Pollution and Incidence of Parkinson's Disease: A Danish Nationwide Administrative Cohort Study.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Overall rehabilitation prognosis for the level of functioning following moderate to severe acquired brain injury: a study using routinely collected health record data.Acta neurologica Belgica · 2026Article
- Early health economic assessment of eLiActa neuropsychiatrica · 2026Article
- Self-reported awareness and knowledge of blunt cerebrovascular injury among emergency, orthopedic, and anesthesiology physicians in Denmark and the Netherlands.International journal of emergency medicine · 2026Article
- Severe Neurological Disorders in the Greenlandic Population: A Nationwide Register-Based Study.Brain and behavior · 2025Article
- Temporomandibular Disorders in Brain Injury Patients and Diagnostic Accuracy of the Assessment Tools.Oral diseases · 2025Article
- Occurrence, mortality, and economic burden of brain disorders in Denmark, 2015-2021: a population-based cohort study.The Lancet regional health. Europe · 2025Article
- Rehabilitation outcomes after comprehensive post-acute inpatient rehabilitation following moderate to severe acquired brain injury-study protocol for an overall prognosis study based on routinely collected health data.Diagnostic and prognostic research · 2025Article
- Artificial intelligence based advancements in nanomedicine for brain disorder management: an updated narrative review.Frontiers in medicine · 2025Review
- Brain Glucose Metabolism andDiagnostics (Basel, Switzerland) · 2024Article
- Mental Health Conditions in Partners and Adult Children of Stroke Survivors.JAMA network open · 2024Article
- Comorbidity, Criminality, and Costs of Patients Treated for Gambling Disorder in Denmark.Journal of gambling studies · 2023Article
- Labour market participation and retirement after stroke in Denmark: registry based cohort study.BMJ (Clinical research ed.) · 2023Article
- Postsurgical morbidity and mortality favorably informs deep brain stimulation for new indications including schizophrenia and schizoaffective disorder.Frontiers in surgery · 2023Article
- Measuring anxiety-like behavior in a mouse model of mTBI: Assessment in standard and home cage assays.Frontiers in behavioral neuroscience · 2023Article
- Study design of an interdisciplinary and participatory nature-based palliative rehabilitation intervention in a Danish nursing home for people with severe dementia.BMC geriatrics · 2022Article
- Risk of dementia in patients with inflammatory bowel disease: a Danish population-based study.Alimentary pharmacology & therapeutics · 2022Article
- The cost of mental disorders in Denmark: a register-based study.Npj mental health research · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo examine the occurrence of brain disorders (ie, neurological and mental disorders) in Denmark and mortality and cost of illness among affected persons.
designMatched cohort study.
settingWe obtained routinely collected registry data on all Danish residents during 1995-2015.
participantsWe identified all persons alive on 1 January 2015 with a diagnosis of 25 specific brain disorders (prevalent cohort) and all persons with an incident diagnosis during 2011-2015 (incident cohort). Each person was matched on age and sex with 10 persons from the general population without the brain disorder of interest. PRIMARY AND SECONDARY OUTCOME MEASURES: Prevalence and incidence of hospital-diagnosed brain disorders, 1-year absolute and relative mortality, and attributable direct and indirect costs of illness compared with the corresponding matched cohorts.
resultsWe identified 1 075 081 persons with at least one prevalent brain disorder (any brain disorder) on 1 January 2015, corresponding to 18.9% of the Danish population. The incidence rate of any brain disorder during 2011-2015 was 1349 per 100 000 person-years (95% CI 1345 to 1353). One-year mortality after diagnosis was increased in persons with any brain disorder (HR 4.7, 95% CI 4.7 to 4.8) and in persons in every group of specific brain disorders compared with the matched cohort from the general population. The total attributable direct costs of brain disorders in 2015 were €5.2 billion and total attributable indirect costs were €11.2 billion. Traumatic brain injury, stress-related disorders, depression and stroke were the most common brain disorders. Attributable costs were highest for depression, dementia, stress-related disorders and stroke.
conclusionsOne in five Danish residents alive on 1 January 2015 had been diagnosed with at least one brain disorder, and mortality was five times higher in persons with any diagnosed brain disorder than in the general population. We found high attributable direct and indirect costs of brain disorders.
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