ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2021
Risk factors for mortality in lung transplant recipients aged ≥65 years: A retrospective cohort study of 5,815 patients in the scientific registry of transplant recipients.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 41 citations in OpenAlex.
- Lung transplantation outcomes in candidates aged ≥ 70 years old: A 10-year single center experience.JHLT open · 2026Article
- Post-transplant predictors of mortality and primary graft dysfunction in lung transplant recipients bridged with veno-venous extracorporeal membrane oxygenation.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2026Article
- Impact of renal function on survival in idiopathic pulmonary fibrosis patients 65 years and older undergoing lung transplantation in the United States.JTCVS open · 2026Article
- Physical Activity Status and Related Factors of Lung Transplant Patients Within One Year After Surgery: A Single-Center Observational Study.Canadian respiratory journal · 2026Observational
- Pulmonary Disease in the Older Adult: A Review of Interstitial Lung Disease.Clinics in geriatric medicine · 2025Review
- Computed Tomography-Based Body Composition is Related to Perioperative Morbidity in Older Lung Transplant Recipients.The Thoracic and cardiovascular surgeon · 2025Article
- Machine Learning for 1-Year Mortality Prediction in Lung Transplant Recipients: ISHLT Registry.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Donor age over 55 is associated with worse outcome in lung transplant recipients with idiopathic pulmonary fibrosis.BMC pulmonary medicine · 2024Article
- Risk factors for mid- and long-term mortality in lung transplant recipients aged 70 years and older.Interdisciplinary cardiovascular and thoracic surgery · 2024Article
- Clinical impact of pre-existing acute exacerbation in patients with interstitial lung disease who underwent lung transplantation.Respiratory research · 2023Article
- Observational Study of the Association between Atrial Fibrillation and In-Hospital Mortality during Hospitalization for Solid Organ Transplants in Spain from 2004 to 2021.Journal of clinical medicine · 2023Article
- Prevalence and significance of clonal hematopoiesis of indeterminate potential in lung transplant recipients.BMC pulmonary medicine · 2023Article
- Trends and Outcomes in Lung Transplantation in Patients with and without Idiopathic Pulmonary Fibrosis in Spain during the Period 2016-2020.Healthcare (Basel, Switzerland) · 2023Article
- Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients aged over 65 years.Frontiers of medicine · 2023Article
- Independent risk factors for an increased incidence of thromboembolism after lung transplantation.Journal of thrombosis and thrombolysis · 2023Article
- Disparities in heart and lung transplantation.Current opinion in organ transplantation · 2021Review
- Lung transplantation for interstitial lung disease.European respiratory review : an official journal of the European Respiratory Society · 2021Review
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5 authors at 3 institutions in 1 country.
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Abstract
backgroundLung transplantation is increasingly performed in recipients aged ≥65 years. However, the risk factors for mortality specific to this population have not been well studied. In lung transplant recipients aged ≥65 years, we sought to determine post-transplant survival and clinical factors associated with post-transplant mortality.
methodsWe investigated 5,815 adult lung transplants recipients aged ≥65 years in the Scientific Registry of Transplant Recipients. Mortality was defined as a composite of recipient death or retransplantation. The Kaplan-Meier method was used to estimate the median time to mortality. Univariable and multivariable Cox proportional hazards regression models were used to examine the association between time to mortality and 23 donor, recipient, or center characteristics.
resultsMedian survival in lung transplant recipients aged ≥65 years was 4.41 years (95% CI: 4.21-4.60 years) and significantly worsened by increasing age strata. In the multivariable model, increasing recipient age strata, creatinine level, bilirubin level, hospitalization at the time of transplantation, single lung transplant operation, steroid use at the time of transplantation, donor diabetes, and cytomegalovirus mismatch were independently associated with increased mortality.
conclusionsAmong the 8 risk factors we identified, 5 factors are readily available, which can be used to optimize post-transplant survival by informing risk during candidate selection of patients aged ≥65 years. Furthermore, bilateral lung transplantation may confer improved survival in comparison with single lung transplantation. Our results support that after careful consideration of risk factors, lung transplantation can provide life-extending benefits in individuals aged ≥65 years.
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