ArticleMolecular autism2020
Common and unique multimodal covarying patterns in autism spectrum disorder subtypes.
Article in Molecular autism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Inferring relationships among major psychiatric disorders in a resting-state functional connectivity-informed embedding space.NPJ systems biology and applications · 2026Article
- Six artificial intelligence innovation strategies applied to autism spectrum disorder research: A narrative review.Pediatric investigation · 2026Review
- Mismatching Expressions: Spatiotemporal and Kinematic Differences in Autistic and Non-Autistic Facial Expressions.Autism research : official journal of the International Society for Autism Research · 2026Article
- Equifinal pathways and subtypes: a developmental neuroimaging perspective on social differences in autism.Frontiers in psychiatry · 2026Article
- Identifying brain functional subtypes and corresponding task performance profiles in autism spectrum disorder.Molecular psychiatry · 2025Article
- Local activity alterations in individuals with autism correlate with neurotransmitter properties and ketamine-induced brain changes.Nature communications · 2025Article
- High-precision machine learning identifies a reproducible functional connectivity signature of autism spectrum diagnosis in a subset of individuals.GigaScience · 2025Article
- Confound Controlled Multimodal Neuroimaging Data Fusion and Its Application to Developmental Disorders.IEEE transactions on image processing : a publication of the IEEE Signal Processing Society · 2025Article
- The promise of precision functional mapping for neuroimaging in psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Abnormal multimodal neuroimaging patterns associated with social deficits in male autism spectrum disorder.Human brain mapping · 2024Article
- Individual Deviation-Based Functional Hypergraph for Identifying Subtypes of Autism Spectrum Disorder.Brain sciences · 2024Article
- Symptom-guided multimodal neuroimage fusion patterns in children with attention-deficit/hyperactivity disorder and its potential "brain structure-function-cognition-behavior" pathological pathways.European child & adolescent psychiatry · 2024Article
- Reduced covariation between brain morphometry and local spontaneous activity in young children with ASD.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Delineating a Pathway for the Discovery of Functional Connectome Biomarkers of Autism.Advances in neurobiology · 2024Review
- Comparison of autism spectrum disorder subtypes based on functional and structural factors.Frontiers in neuroscience · 2024Article
- Intrinsic neural timescales in autism spectrum disorder and schizophrenia. A replication and direct comparison study.Schizophrenia (Heidelberg, Germany) · 2023Article
- Individual brain regulation as learned via neurofeedback is related to affective changes in adolescents with autism spectrum disorder.Child and adolescent psychiatry and mental health · 2023Article
- Psychotic Symptom, Mood, and Cognition-associated Multimodal MRI Reveal Shared Links to the Salience Network Within the Psychosis Spectrum Disorders.Schizophrenia bulletin · 2023Article
- Data-driven multimodal fusion: approaches and applications in psychiatric research.Psychoradiology · 2023Review
- Inter-individual heterogeneity of functional brain networks in children with autism spectrum disorder.Molecular autism · 2022Article
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9 authors.
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Abstract
backgroundThe heterogeneity inherent in autism spectrum disorder (ASD) presents a substantial challenge to diagnosis and precision treatment. Heterogeneity across biological etiologies, genetics, neural systems, neurocognitive attributes and clinical subtypes or phenotypes has been observed across individuals with ASD.
methodsIn this study, we aim to investigate the heterogeneity in ASD from a multimodal brain imaging perspective. The Autism Diagnostic Observation Schedule (ADOS) was used as a reference to guide functional and structural MRI fusion. DSM-IV-TR diagnosed Asperger's disorder (n = 79), pervasive developmental disorder-not otherwise specified [PDD-NOS] (n = 58) and Autistic disorder (n = 92) from ABIDE II were used as discovery cohort, and ABIDE I (n = 400) was used for replication.
resultsDorsolateral prefrontal cortex and superior/middle temporal cortex are the primary common functional-structural covarying cortical brain areas shared among Asperger's, PDD-NOS and Autistic subgroups. Key differences among the three subtypes are negative functional features within subcortical brain areas, including negative putamen-parahippocampus fractional amplitude of low-frequency fluctuations (fALFF) unique to the Asperger's subtype; negative fALFF in anterior cingulate cortex unique to PDD-NOS subtype; and negative thalamus-amygdala-caudate fALFF unique to the Autistic subtype. Furthermore, each subtype-specific brain pattern is correlated with different ADOS subdomains, with social interaction as the common subdomain. The identified subtype-specific patterns are only predictive for ASD symptoms manifested in the corresponding subtypes, but not the other subtypes.
conclusionsAlthough ASD has a common neural basis with core deficits linked to social interaction, each ASD subtype is strongly linked to unique brain systems and subdomain symptoms, which may help to better understand the underlying mechanisms of ASD heterogeneity from a multimodal neuroimaging perspective. LIMITATIONS: This study is male based, which cannot be generalized to the female or the general ASD population.
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