Evidence map›Paper›PMID 33208019›Full record

ArticleJournal of the American Heart Association2020

Twenty-Four-Hour Cardiovascular Effects of Electronic Cigarettes Compared With Cigarette Smoking in Dual Users.

Neal L Benowitz, Gideon St Helen, Natalie Nardone, Newton Addo, Junfeng Jim Zhang, Arit M Harvanko, Carolyn S Calfee, Peyton Jacob

Abstract readComparative Study
In one paragraph

Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Review
  8. Review
  9. Review
  10. Electronic Cigarette Use and the Risk of Cardiovascular Diseases.Frontiers in cardiovascular medicine · 2022
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Neal L BenowitzClinical Pharmacology Research Program Division of Cardiology Department of Medicine University of California San Francisco CA.
Gideon St HelenClinical Pharmacology Research Program Division of Cardiology Department of Medicine University of California San Francisco CA.
Natalie NardoneClinical Pharmacology Research Program Division of Cardiology Department of Medicine University of California San Francisco CA.
Newton AddoClinical Pharmacology Research Program Division of Cardiology Department of Medicine University of California San Francisco CA.
Junfeng Jim ZhangGlobal Health Institute & Nicholas School of the Environment Duke University Durham NC.
Arit M HarvankoClinical Pharmacology Research Program Division of Cardiology Department of Medicine University of California San Francisco CA.
Carolyn S CalfeeDivision of Pulmonary Critical Care Allergy and Sleep Medicine Department of Medicine University of California San Francisco CA.
Peyton JacobClinical Pharmacology Research Program Division of Cardiology Department of Medicine University of California San Francisco CA.

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
PROJECT 5: IMPACT OF CHANGING TOBACCO PRODUCT USE ON HEALTHCARE COSTS FOR GENERAL AND VULNERABLE POPULATIONSU54HL147127 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GLANTZ, STANTON ARNOLD · 2018 to 2022
$20.4M
Research Support CoreP30DA012393 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JACOB, PEYTON, JONES, REESE T. · 1999 to 2024
$17.1M
Mentoring Emerging Scientists for Careers in Substance Use ResearchR25DA035163 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Carmen L Masson, Gideon St.Helen · 2014 to 2026
$4.6M
Clinical Pharmacology of Electronic CigarettesR01DA039264 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BENOWITZ, NEAL L · 2015 to 2021
$4.5M
Postdoctoral training in tobacco controlT32CA113710 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LING, PAMELA MAY · 2016 to 2020
$2.6M
NCI NIH HHS T32 CA113710NCRR NIH HHS UL1 RR024131NHLBI NIH HHS U54 HL147127NIDA NIH HHS P30 DA012393NIDA NIH HHS R01 DA039264NIDA NIH HHS R25 DA035163
6 · The paper itself

Abstract

Background Cardiovascular safety is an important consideration regarding the benefits versus risks of electronic cigarette use (EC) for public health. The single-use cardiovascular effects of EC have been well studied but may not reflect effects of ad libitum use throughout the day. We aimed to compare the circadian hemodynamic effects as well as 24-hour biomarkers of oxidative stress, and platelet aggregation and inflammation, with ad libitum cigarette smoking (CS) versus EC versus no tobacco product use. Methods and Results Thirty-six healthy dual CS and EC users participated in a crossover study in a confined research setting. Circadian heart rate, blood pressure and plasma nicotine levels, 24-hour urinary catecholamines, 8-isoprostane and 11-dehydro-thromboxane B2, and plasma interleukin-6 and interleukin-8 were compared in CS, EC, and no nicotine conditions. Over 24 hours, and during daytime, heart rate and blood pressure were higher in CS and EC compared with no tobacco product conditions (

Indexed as

Cigarette SmokingElectronic Nicotine Delivery SystemsVapingAdultBiomarkersBlood PressureCatecholaminesCircadian RhythmCross-Over StudiesFemaleHeart RateHumansMaleMiddle AgedNicotineOxidative StressBiomarkersCatecholaminesNicotinebiomarkerselectronic cigarettesnicotinetobacco

Identifiers

PMID33208019
PMCPMC7763797

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.