Evidence map›Paper›PMID 33207791›Full record

ArticleInternational journal of molecular sciences2020

The Transcription Factor HAND1 Is Involved in Cortical Bone Mass through the Regulation of Collagen Expression.

Noriko Funato, Yuki Taga, Lindsay E Laurie, Chisa Tometsuka, Masashi Kusubata, Kiyoko Ogawa-Goto

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Genes · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Noriko FunatoDepartment of Signal Gene Regulation, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.ORCID 0000-0002-1320-3304
Yuki TagaNippi Research Institute of Biomatrix, 520-11 Kuwabara, Toride, Ibaraki 302-0017, Japan.
Lindsay E LaurieDepartment of Signal Gene Regulation, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Chisa TometsukaNippi Research Institute of Biomatrix, 520-11 Kuwabara, Toride, Ibaraki 302-0017, Japan.
Masashi KusubataNippi Research Institute of Biomatrix, 520-11 Kuwabara, Toride, Ibaraki 302-0017, Japan.
Kiyoko Ogawa-GotoNippi Research Institute of Biomatrix, 520-11 Kuwabara, Toride, Ibaraki 302-0017, Japan.
Japan Institute of Leather Research · JPTokyo Medical and Dental University · JP

Funding

Japan Science and Technology Agency Initiative for realizing diversity in the research environmentJapan Society for the Promotion of Science 22390340, 20K09901
6 · The paper itself

Abstract

Temporal and/or spatial alteration of collagen family gene expression results in bone defects. However, how collagen expression controls bone size remains largely unknown. The basic helix-loop-helix transcription factor HAND1 is expressed in developing long bones and is involved in their morphogenesis. To understand the functional role of HAND1 and collagen in the postnatal development of long bones, we overexpressed

Indexed as

Gene Expression RegulationAnimalsBasic Helix-Loop-Helix ProteinsCollagenCore Binding Factor Alpha 1 SubunitCortical BoneDiaphysesMiceMice, TransgenicOrgan SizeSp7 Transcription FactorBasic Helix-Loop-Helix ProteinsCollagenCore Binding Factor Alpha 1 SubunitHand1 protein, mouseRunx2 protein, mouseSp7 protein, mouseSp7 Transcription Factorcollagencortical bonemicroRNAsperiosteumtranscription factorsX-ray microtomography

Identifiers

PMID33207791
PMCPMC7697595
OpenAlexW3106038861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.